14.3.3 sigma antibody (BSA/Azide Free) (10R-S101ap)

Mouse monoclonal 14.3.3 Sigma antibody (BSA/Azide Free)

Synonyms Monoclonal 14.3.3 Sigma antibody, Anti-14.3.3 Sigma antibody, 14/3/3 sigma, 14/3/3 sigma antibody, 14-3-3 sigma antibody, 14.3.3 sigma, 14-3-3 Sigma antibody, 14-3-3 sigma
Specificity Human
Cross Reactivity To be determined by end-user
Applications IF, IHC-F, IHC-P, IP
Immunogen 14.3.3 Sigma antibody (BSA/Azide-free) was raised in mouse using recombinant human 14-3-3 sigma protein as the immunogen.

Images

Immunohistochemical staining using 14.3.3 sigma antibody (BSA/Azide Free) (10R-S101ap)

Formalin-fixed, paraffin-embedded human skin stained with 14.3.3 sigma antibody using peroxidase-conjugate and AEC chromogen. Note cytoplasmic staining of epidermis.

Specifications

Host Mouse
Clone 1433S01
Isotype IgG1 kappa
Method of Purification 14.3.3 Sigma antibody (BSA/Azide Free) was purified by Protein G chromatography.
Molecular Weight 26-30 kDa (predicted detection band MW)
Form & Buffer Antibody purified from ascites fluid by protein G chromotography and supplied in 10mM PBS, pH 7.4.
Concentration Batch dependent - please inquire should you have specific requirements

Usage & Assay Information

Usage Recommendations IHC-F: 2-4 ug/ml, IHC-P: 2-4 ug/ml, IP: 2 ug/ml protein lysate

Storage & Safety

Storage Store at 4 deg C.

General Information

Biological Significance 14-3-3 proteins are a family of small, widely expressed, highly conserved cytosolic proteins. 14-3-3 proteins bind to and influence the activities of a diverse group of molecules involved in signal transduction, cell cycle regulation and apoptosis, including Raf, PKC, Bad, Cbl, and c-Bcr. Interactions between 14-3-3 and target proteins are strongly influenced by the phosphorylation state of 14-3-3 and the target protein. 14-3-3 sigma shares cyclin-Cdk2 binding motifs with different cell cycle regulators, including p107, p130, p21Cip1, p27Kip1, and p57Kip2 and is associated with cyclin-Cdk complexes in vitro and in vivo.

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Images

  • Immunohistochemical staining using 14.3.3 sigma antibody (BSA/Azide Free) (10R-S101ap) | Formalin-fixed, paraffin-embedded human skin stained with 14.3.3 sigma antibody using peroxidase-conjugate and AEC chromogen. Note cytoplasmic staining of epidermis.

Availability: In stock

Price: €757.38
Size: 200 ug
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