41BB ligand protein (His tag) (80R-1143)
Purified recombinant Human 41BB ligand protein
|Synonyms||CD137L protein, 4 1BB L protein, 4 1BB ligand protein, ILA ligand (TNF related) protein, 4 1BBL protein, TNFSF9 protein, Cd157l protein, Ly63l protein, Cd137l protein, Tumor necrosis factor ligand superfamily member 9 protein, 4-1BBL protein, 4-1BB ligand protein, receptor 4 1BB ligand protein, Tumor necrosis factor (ligand) superfamily member 9., homolog of mouse 4 1BB L protein, homolog of mouse 4 1BBL protein|
Coomassie Blue stained SDS-PAGE of 41BB ligand protein (His tag) (80R-1143)
Figure annotation denotes ug of protein loaded and % gel used.
|Residues||71-254 amino acids: MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSHMRE GPELSPDDPA GLLDLRQGMF AQLVAQNVLL IDGPLSWYSD PGLAGVSLTG GLSYKEDTKE LVVAKAGVYY VFFQLELRRV VAGEGSGSVS LALHLQPLRS AAGAAALALT VDLPPASSEA RNSAFGFQGR LLHLSAGQRL GVHLHTEARA RHAWQLTQGA TVLGLFRVTP EIPAGLPSPR SE|
|Grade & Purity||> 95% pure|
|Molecular Weight||23.8 kDa (222aa), confirmed by MALDI-TOF.|
|Form & Buffer||Supplied as a liquid in 20mM Tris-HCl buffer, pH 8.0, containing 100mM NaCl, and 20% glycerol.|
Storage & Safety
|Storage||Store at 4 deg C for short term storage (1/2 weeks). Aliquot and store at -20 deg C or - 70 deg C for long term storage. Avoid repeated freeze/thaw cycles.|
|Biological Significance||4-1BB ligand is a type 2 transmembrane glycoprotein belonging to the TNF superfamily. 4-1BBL is expressed by activated B cells, macrophages, dendritic cells, activated T cells, neurons and astrocytes. The interaction of 4-1BB with 4-1BBL strongly regulates immunity and has been proposed to preferentially control T cell responses based on studies in various murine models of cancer, infectious disease and autoimmune disease. Recombinant human 4-1BB ligand, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography.|
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