Adenovirus type 5 hexon protein (30-1851)

Purified Native Adenovirus type 5 hexon protein

Synonyms Adenovirus type 5 hexon antigen, Adenovirus type 5 protein, Adenovirus hexon protein
Species Viral
Protein Type Native

Specifications

Source Purified hexon protein
Grade & Purity > 99% pure
Form & Buffer Supplied in 10mM Bis Tris Propane, 375 mM NaCl
Concentration 200-600 ug/ml

Storage & Safety

Storage Store at -80 deg C

General Information

Product Use Adenovirus type 5 hexon protein for use in the research laboratory
Biological Significance In molecular biology, the hexon protein is a major coat protein found in Adenoviruses. Hexon coat proteins are synthesised during late infection and form homo-trimers.
Expression Hexon coat proteins are synthesised during late stage Adenovirus infection and form homo-trimers.
Implications in Disease Hexon protein naturally self assembles as part of the virus life cycle. When the protein is purified we also see evidence of self assembly such as rapid loss of protein upon serial dilution. Hexon directly recruits the cellular motor protein dynein in a pH-dependent manner. The dynein-regulatory protein, dynactin, was found to play a clear role in regulating the dynein-adenovirus complex transport to the nucleus.
Sequence Information The 240 copies of the hexon trimer that are produced are organised so that 12 lie on each of the 20 facets. The central 9 hexons in a facet are cemented together by 12 copies of polypeptide IX. The penton complex, formed by the peripentonal hexons and base hexon (holding in place a fibre), lie at each of the 12 vertices. The hexon coat protein is a duplication consisting of two domains with a similar fold packed together like the nucleoplasmin subunits. Within a hexon trimer, the domains are arranged around a pseudo 6-fold axis. The domains have a beta-sandwich structure consisting of 8 strands in two sheets with a jelly-roll topology; each domain is heavily decorated with many insertions. Some hexon proteins contain a distinct C-terminal domain.

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Price From: Price: €280.57
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