Adipolean Variant antibody (70R-AR009)

Affinity purified Rabbit polyclonal Adipolean Variant antibody

Synonyms Polyclonal Adipolean Variant antibody, Anti-Adipolean Variant antibody
Specificity Human adipolean variant
Cross Reactivity To be determined by end-user
Applications ELISA, Inhibition, WB
Immunogen Adipolean Variant antibody was raised in rabbit using highly pure recombinant human adipolean variant as the immunogen.

Specifications

Host Rabbit
Form & Buffer Lyophilized from PBS, pH 7.2.

Usage & Assay Information

Usage Recommendations Optimal conditions to be determined by end user

Storage & Safety

Storage Store at -20 deg C until reconstitution. Following reconstitution product may be stored at 4 deg C in the short term. For long term storage aliquot and freeze at -20 deg C. Avoid repeated freeze/thaw cycles.

General Information

Biological Significance The adipolean variant is an important adipokine involved in the control of fat metabolism and insulin sensitivity, with direct anti-diabetic, anti-atherogenic and anti-inflammatory activities. It stimulates AMPK phosphorylation and activation in the liver and the skeletal muscle, enhancing glucose utilization and fatty-acid combustion. The adipolean variant antagonizes TNF-alpha by negatively regulating its expression in various tissues such as liver and macrophages, and also by counteracting its effects. It also inhibits endothelial NF-kappa-B signaling through a cAMP-dependent pathway.

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Availability: In stock

Price: €211.69
Size: 50 ug
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