AID antibody (biotin) (61R-2066)
Rat monoclonal AID antibody (biotin)
Overview
Overview
| Synonyms | Monoclonal AID antibody, Anti-AID antibody, Activation-induced deaminase antibody, Aicda antibody, Aid antibody, Activation-induced cytidine deaminase antibody, Arp2 antibody, Cytidine aminohydrolase antibody |
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| Specificity | Human |
| Cross Reactivity | Human, Mouse |
| Applications | IHC, IHC-F, WB |
Specifications
| Host | Rat |
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| Isotype | IgG2a kappa |
| Tag/Conjugate | Biotin |
| Form & Buffer | Supplied in an aqueous buffer with 0.09% sodium azide, may contain carrier protein/stabilizer |
| Concentration | 500 ug/ml |
Storage & Safety
| Storage | Store at 2-8 deg C |
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General Information
| Biological Significance | AID is a 24 kDa RNA-editing enzyme that converts cytosine into uracil. It plays a critical role during B cell development, specifically in somatic hypermutation (SHM) and immunoglobulin class switch recombination (CSR). Changes in levels of AID expression typically present with disease. For example, mutations in AID are found in Hyper-IgM Syndrome (type 2), a disease form without opportunistic infections, while overexpression correlates with poor prognosis in chronic lymphocytic leukemia/small lymphocytic lymphoma. |
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