Alix protein (His tag) (80R-1259)
Purified recombinant Human Alix protein
|Synonyms||PDC6I protein, ALG2 interacting protein X protein, DRIP4 protein, KIAA1375 protein, Programmed cell death 6 interacting protein ALG 2 interacting protein 1 protein, HP95 protein, MGC17003 protein, Programmed cell death 6 interacting protein., AIP1 protein, Dopamine receptor interacting protein 4 protein, PDCD6IP protein, PDCD6 interacting protein protein, Apoptosis linked gene 2 interacting protein X protein|
Coomassie Blue stained SDS-PAGE of Alix protein (His tag) (80R-1259)
Figure annotation denotes ug of protein loaded and % gel used.
|Residues||1-392 amino acids: MGSSHHHHHH SSGLVPRGSH MATFISVQLK KTSEVDLAKP LVKFIQQTYP SGGEEQAQYC RAAEELSKLR RAAVGRPLDK HEGALETLLR YYDQICSIEP KFPFSENQIC LTFTWKDAFD KGSLFGGSVK LALASLGYEK SCVLFNCAAL ASQIAAEQNL DNDEGLKIAA KHYQFASGAF LHIKETVLSA LSREPTVDIS PDTVGTLSLI MLAQAQEVFF LKATRDKMKD AIIAKLANQA ADYFGDAFKQ CQYKDTLPKE VFPVLAAKHC IMQANAEYHQ SILAKQQKKF GEEIARLQHA AELIKTVASR YDEYVNVKDF SDKINRALAA AKKDNDFIYH DRVPDLKDLD PIGKATLVKS TPVNVPISQK FTDLFEKMVP VSVQQSLAAY NQRKADLVNR SIAQMREATT LA|
|Grade & Purity||> 95% pure|
|Molecular Weight||45.8 kDa (412aa), confirmed by MALDI-TOF.|
|Form & Buffer||Supplied as a liquid in 20mM Tris-HCl buffer, pH 8.0, containing 10% glycerol and 1mM DTT.|
Storage & Safety
|Storage||Store at 4 deg C for short term storage (1/2 weeks). Aliquot and store at -20 deg C or - 70 deg C for long term storage. Avoid repeated freeze/thaw cycles.|
|Biological Significance||Alix, also known as PDCD6IP, is a cytoplasmic protein that interacts with apoptosis-associated proteins (ALG-2 and PDCD6) and with the endocytosis-regulator CIN85. It?s involved in concentration and sorting of cargo proteins of the multivesicular body for incorporation into intralumenal vesicles that are generated by invagination and scission from the limiting membrane of the endosome. Overexpression of this protein and endophilins results in cytoplasmic vacuolization which may be partly responsible for the protection against cell death. Recombinant PDCD6IP protein was expressed in E. coli and purified by using conventional chromatography techniques.|
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