alpha Crystallin A antibody (10R-1002)

Mouse monoclonal alpha Crystallin A antibody

Synonyms Monoclonal A crystallin A antibody, Anti-A crystallin A antibody, HSPB 4 antibody, alpha crystallin A chain antibody, Heat shock protein beta-4 antibody, CRYAA antibody, Heat shock protein beta 4 antibody, Crystallin alpha A antibody, alpha-crystallin A chain antibody, Crystallin alpha 1 antibody, CRYA 1 antibody, HspB4 antibody, CRYA1 antibody, Acry-1 antibody, Zonular Central Nuclear Cataract antibody
Specificity Human
Cross Reactivity Human, Rat
Applications ELISA, WB
Immunogen alpha Crystallin A antibody was raised in mouse using recombinant human Crystallin alpha A (1-173aa) purified from E. coli as the immunogen.

Specifications

Host Mouse
Clone c9F2
Isotype IgG1 kappa
Source Anti-human Crystallin alpha A antibody, clone c9F2, is derived from hybridization of mouse SP2/O myeloma cells with spleen cells from BALB/c mice immunized with recombinant Crystallin alpha A.
Method of Purification alpha Crystallin A antibody was purified by protein-G affinity chromatography
Form & Buffer Supplied as a liquid in PBS, pH 7.4, with 0.1% NaN3.
Concentration 1 mg/ml

Usage & Assay Information

Usage Recommendations WB: 1:500-1:2,000

Storage & Safety

Storage Store at 4 deg C for short term storage. Aliquot and store at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles.

General Information

Biological Significance alpha-crystallins, a major protein of the ocular lens, are thought to play a role in maintaining lens transparency, and composed of two gene products alpha-A and alpha-B, for acidic and basic, respectively. alpha-crystallins can be induced by heat shock and are members of the small heat shock protein (sHSP). They act as molecular chaperones and hold unfolded or misfolded proteins in large, water-soluble low molecular weight aggregates. These heterogeneous aggregates consist of 30-40 subunits of the alpha-A and alpha-B subunits have a 3:1 ratio, respectively. Two additional function of alpha-crystallins are an autokinase activity and the participation in the intracellular architecture.

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Availability: In stock

Price: €249.33
Size: 100 ul
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