alpha Synuclein antibody (10R-1837)

Mouse monoclonal alpha Synucleinantibody

Synonyms Monoclonal Synuclein Alpha antibody, Anti-Synuclein Alpha antibody, NACP antibody, SNCA antibody, Non A4 Component Of Amyloid Precursor antibody, PARK1 antibody, NACP antibody, Non A4 Component Of Amyloid Precursor antibody, PARK4 antibody, MGC110988 antibody, PD1 antibody, PD1 antibody, SNCA antibody, Synuclein Alpha antibody, MGC110988 antibody, Anti Synuclein Alpha antibody, PARK4 antibody, PARK1 antibody
Cross Reactivity Human
Applications ELISA, IHC, WB
Immunogen alpha Synuclein antibody was raised in Mouse using a purified recombinant fragment of SNCA expressed in E. coli as the immunogen.

Images

Immunohistochemical staining using Synuclein Alpha antibody (10R-1837)

Immunohistochemical analysis of paraffin-embedded human glioma tissue, showing membrane localization using SNCA antibody with DAB staining.

Specifications

Host Mouse
Clone 2B2D1, 2B2A11
Form & Buffer Supplied as a liquid in ascitic fluid containing 0.03% sodium azide.
Concentration 1.0 mg/ml

Usage & Assay Information

Usage Recommendations ELISA: 1:10,000, IHC: 1:200-1:1000, WB: 1:500-1:2000

Storage & Safety

Storage Store at 4 deg C for short term storage. Store at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles.

General Information

Biological Significance SNCA belongs to the synuclein family, which also includes beta- and gamma-synuclein. SNCA is a soluble protein, expressed principally in the brain but also expressed in low concentrations in all tissues examined (except liver). SNCA is implicated in the regulation of dopamine release and transport. The triplication of the SNCA can cause Parkinson disease (PD) and diffuse Lewy body disease within the same kindred. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Immunohistochemistry for SNCA has become the histological technique of choice for the diagnosis for Parkinson's disease, Dementia with Lewy bodies and Multiple System Atrophy.

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Images

  • Immunohistochemical staining using Synuclein Alpha antibody (10R-1837) | Immunohistochemical analysis of paraffin-embedded human glioma tissue, showing membrane localization using SNCA antibody with DAB staining.
  • Western Blot analysis using Synuclein Alpha antibody (10R-1837) | Western Blot showing SNCA antibody used against truncated SNCA recombinant protein.

Availability: In stock

Price: €285.10
Size: 100 ul
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