alpha1 antichymotrypsin antibody (10R-8449)
Mouse monoclonal alpha1 antichymotrypsin antibody
Overview
Overview
| Synonyms | Monoclonal alpha1 antichymotrypsin antibody, Anti-alpha1 antichymotrypsin antibody, SERPINA3 antibody, serpin peptidase inhibitor antibody, clade A (alpha-1 antiproteinase antibody, antitrypsin) antibody, member 3 antibody, AACT antibody, ACT antibody, alpha-1-antichymotrypsin antibody, BOS_20523 antibody, cell growth-inhibiting gene 24/25 protein antibody, GIG24 antibody, GIG25 antibody, growth-inhibiting protein 24 antibody, growth-inhibiting protein 25 antibody, serine (or cysteine) proteinase inhibitor antibody, clade A (alpha-1 antiproteinase antibody, antitrypsin) antibody, member 1 antibody, serine (or cysteine) proteinase inhibitor antibody, clade A antibody, member 3 antibody, serine proteinase inhibitor antibody, clade A antibody, member 1 antibody, serpina1 antibody, serpin A3 antibody, serpin A3-5 antibody, SERPINA3-5 antibody, serpin peptidase inhibitor antibody, clade A antibody, member 3 antibody |
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| Cross Reactivity | Human |
| Applications | IHC-P, WB |
| Immunogen | alpha1 antichymotrypsin antibody was raised in Mouse using a protein purified from Human plasma as the immunogen |
Specifications
| Host | Mouse |
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| Clone | 71A1 |
| Isotype | IgG1 kappa |
| Method of Purification | alpha1 antichymotrypsin antibody was purified by ammonium sulfate precipitation |
| Form & Buffer | Supplied in liquid form in HEPES buffer with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol |
Usage & Assay Information
| Usage Recommendations | WB: 1:1000 |
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Storage & Safety
| Storage | Aliquot and store for 1 year at -20 deg C, avoid freeze/thaw cycles |
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General Information
| Biological Significance | alpha-1-antichymotrypsin (ACT) is a glycoprotein with a molecular weight of 55~68 kDa and 25% by weight of various sugars, whose heterogeneity results in variation of molecular weight. It inhibits chymotrypsin-like proteinases in vivo and has cytotoxic killer-cell activity in vitro. The protein also has a role as an acute-phase protein and is active in the control of immunologic and inflammatory processes, and as a tumor marker. Plasma ACT levels might increase rapidly more than 5-fold during an acute phase reaction, ACT has been shown to promote Abeta polymerization in vitro and in vivo, and levels of ACT protein in plasma and cerebrospinal fluid from Alzheimer's patients have been found to correlate with progression of dementia. |
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