Angiopoietin 2 antibody (10-2265)
Recombinant Fab monoclonal Angiopoietin 2 antibody
Overview
Overview
| Synonyms | Monoclonal Angiopoietin 2 antibody, Anti-Angiopoietin 2 antibody, angiopoietin-2a antibody, angiopoietin-2B antibody, ANGP2 antibody, ANGPT2 antibody, Tie2-ligand antibody, AGPT2 antibody, ANG-2 antibody, ANG2 antibody, angiopoietin2 antibody, Angiopoietin-2 antibody |
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| Specificity | Human |
| Protein Type | Recombinant |
| Applications | ELISA |
| Assay Information | Angiopoietin 2 antibody pair: 10-2264 can be used as the capture antibody with 10-2265 as the detection antibody for detection of human Angiopoietin 2 in ELISA |
Specifications
| Host | Mouse |
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| Clone | M72048 |
| Isotype | IgG1 kappa - Fab fragment |
| Expression System | E.coli |
| Grade & Purity | > 95% pure |
| Method of Purification | Angiopoietin 2 antibodies screened using Phage Display system. Expressed in and purified from E. coli. |
| Tag/Conjugate | His tag |
| Form & Buffer | Supplied as liquid in 50 mM Potassium Phosphate, 10 mM Boric Acid, 150 mM NaCl, pH 7 |
| Concentration | > 1 mg/ml |
Storage & Safety
| Storage | Store at -20 deg C in small aliquots. Avoid repeated freeze thawing. |
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General Information
| Biological Significance | Angiopoietin 2 binds to TEK/TIE2, competing for the ANGPT1 binding site, and modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2 in the absence of ANGPT1. In the absence of angiogenic inducers, such as VEGF, ANGPT2-mediated loosening of cell-matrix contacts may induce endothelial cell apoptosis with consequent vascular regression. In concert with VEGF, it may facilitate endothelial cell migration and proliferation, thus serving as a permissive angiogenic signal. Angiopoietin 2 antibody was produced as a recombinant Fab monoclonal antibody in a Phage Display system. This anti-Angiopoietin 2 antibody is used for detection of human Angiopoietin 2 in ELISA. The concentration of the antibody ranges from 1 mg/ml to 25 mg/ml depending on the lot. Recombinant Fab monoclonal antibodies have a number of advantages over standard antibodies including; improved scale up for batch consistency, more efficient binding so less antibody required, more accurate binding meaning fewer conjugation issues, less non specific due to removal of the Fc region, more flexibility for purification and labeling through a C-terminal His tag. |
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