ANGPTL3 protein (80R-4294)
Purified Recombinant ANGPTL3 protein (His tagged)
Overview
Overview
| Synonyms | ANG-5 protein, ANGPT5 protein, ANL3 protein, FHBL2 protein |
|---|---|
| Species | Human |
| Protein Type | Recombinant |
| Applications | SDS-PAGE |
Images
SDS-PAGE analysis using ANGPTL3 protein (His tag) (80R-4294)
Figure annotation denotes ug of protein loaded and % gel used.
Specifications
| Residues | 243-460 aa: MGSSHHHHHH SSGLVPRGSH MPAECTTIYN RGEHTSGMYA IRPSNSQVFH VYCDVISGSP WTLIQHRIDG SQNFNETWEN YKYGFGRLDG EFWLGLEKIY SIVKQSNYVL RIELEDWKDN KHYIEYSFYL GNHETNYTLH LVAITGNVPN AIPENKDLVF STWDHKAKGH FNCPEGYSGG WWWHDECGEN NLNGKYNKPR AKSKPERRRG LSWKSQNGRL YSIKSTKMLI HPTDSESFE |
|---|---|
| Expression System | E.coli |
| Grade & Purity | > 90% pure |
| Molecular Weight | 27.7 kDa |
| Tag/Conjugate | His tag |
| Form & Buffer | Supplied in liquid form in 20 mM Tris-HCl (pH 8.0) containing 10% glycerol |
| Concentration | 1 mg/ml |
Storage & Safety
| Storage | Store at 4 deg C for short term storage. For long term storage, aliquot and store at -20 or -70 deg C. Avoid repeat freeze/thaw cycles |
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General Information
| Biological Significance | ANGPTL3 also known as Angiopoietin-related protein 3 is a member of the angiopoietin-like family of secreted factors. It is expressed predominantly in the liver, and has the characteristic structure of angiopoietins, consisting of a signal peptide, N-terminal coiled-coil domain, and the C-terminal fibrinogen (FBN)-like domain. The FBN-like domain in angiopoietin-like 3 protein was shown to bind alpha-5/beta-3 integrins, and this binding induced endothelial cell adhesion and migration. This protein may also play a role in the regulation of angiogenesis. Recombinant human ANGPTL3, fused to His-tag at N-terminus, was expressed in E.coli. |
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