Polyclonal ANGPTL4 antibody, Anti-ANGPTL4 antibody, ANGPTL 4, ANGPTL-4 antibody, ANGPTL-4, ANGPTL 4 antibody, Angiopoietin like protein 4 antibody, ANGPTL4
Applications
WB
Immunogen
ANGPTL4 antibody was raised in Rabbit using a synthetic peptide corresponding to a sequence at the C-terminal of human Angptl4, different from the related rat and Rabbit sequences by one amino acid, as the immunogen
Optimal conditions to be determined by the end user
Storage & Safety
Storage
Store at 4 deg C for short term storage. For long term storage aliquot and store at -20 deg C, avoid repeated freeze/thaw cycles.
General Information
Biological Significance
ANGPTL4 is a secreted adipokine predominantly expressed in adipose tissue and liver. The experimental results show that ANGPTL4 is a blood-borne hormone directly involved in regulating glucose homeostasis, lipid metabolism, and insulin sensitivity. Serum levels of ANGPTL4 were decreased in patients with type 2 diabetes. In animal experiments, ANGPTL4 treatments might reduce hyperglycemia, and improve glucose tolerance by decreasing hepatic glucose production and enhancing insulin-mediated inhibition of gluconeogenesis. However, the molecular mechanisms underlying its metabolic actions remain elusive.