Annexin A1 protein (30R-1291)
Purified recombinant Human Annexin A1 protein
|Synonyms||Annexin A-1, AnnexinI protein, Chromobindin9 protein, Chromobindin-9 protein, Lipocortin I protein, Phospholipase A2 inhibitory protein protein, HGNC:533 protein, Annexin I protein, Lipocortin 1 protein, Annexin A 1, ANXA 1 protein, Calpactin II protein, CalpactinII protein, p35 protein, , AnnexinA1 protein, Annexin A1, LipocortinI protein, Lipocortin1 protein, ANX1 protein, LPC 1 protein, ANX 1 protein, Lipocortin I protein, ANX A1 protein, Annexin A 1 protein, ANXA1 protein, Chromobindin 9 protein, ANXA1 protein protein, LPC1 protein, Annexin-1 protein, Annexin A-1 protein|
Coomassie Blue stained SDS-PAGE of Annexin A1 protein (30R-1291)
Figure annotation denotes ug of protein loaded and % gel used.
|Residues||1-346 amino acids: MAMVSEFLKQ AWFIENEEQE YVQTVKSSKG GPGSAVSPYP TFNPSSDVAA LHKAIMVKGV DEATIIDILT KRNNAQRQQI KAAYLQETGK PLDETLKKAL TGHLEEVVLA LLKTPAQFDA DELRAAMKGL GTDEDTLIEI LASRTNKEIR DINRVYREEL KRDLAKDITS DTSGDFRNAL LSLAKGDRSE DFGVNEDLAD SDARALYEAG ERRKGTDVNV FNTILTTRSY PQLRRVFQKY TKYSKHDMNK VLDLELKGDI EKCLTAIVKC ATSKPAFFAE KLHQAMKGVG TRHKALIRIM VSRSEIDMND IKAFYQKMYG ISLCQAILDE TKGDYEKILV ALCGGN|
|Grade & Purity||> 90% pure|
|Molecular Weight||38.7 kDa (346aa), confirmed by MALDI-TOF.|
|Form & Buffer||Supplied as a liquid in 20mM Tris-HCl buffer, pH 8.0, containing 100mM NaCl, 1mM DTT, and 10% glycerol.|
Storage & Safety
|Storage||Store at 4 deg C for short term storage (1/2 weeks). Aliquot and store at -20 deg C or - 70 deg C for long term storage. Avoid repeated freeze/thaw cycles.|
|Biological Significance||Annexin A1, also known as Lipocortin I, belongs to a family of Ca(2+)-dependent phospholipid binding proteins that are preferentially located on the cytosolic face of the plasma membrane. It promotes membrane fusion and is also involved in exocytosis. Since Annexin A1 has phospholipase A2 inhibitory activity to bind from two to four calcium ions with high affinity, this protein may have potential anti-inflammatory activity. The detection of this protein by immunocytochemical means reportedly provides a simple, highly sensitive and specific assay for diagnosis of hairy cell leukemia. Recombinant human Annexin A1 protein was expressed in E. coli and purified by using conventional chromatography.|
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