p53 antibodies are commonly used in cancer studies. p53 also known as tumor supressor p53 or tumor antigen p53 is one of the most important tumor suppressor proteins in the human body. Its name is a reference to its molecular weight of 53 kDa. P53 is a powerful regulator of the cell cycle and induces cellular growth arrest or apoptosis in tumors depending on the physiological circumstances and cell type. p53 regulates a large number of genes that control a number of key tumor suppressing functions such as cell cycle arrest, DNA repair, senescence and apoptosis.
P53 levels and post-translational modification state alter in response to cellular stress such as DNA damage, hypoxia, spindle damage etc. Mutations in the P53 gene are commonly found in multiple different cancers, likewise P53 inactivation is a common feature of many tumors, confirming its importance as one of the main tumor suppressor proteins.
P53 powerful tumor suppression abilities along with its ability to detect DNA damage and abnormal cellular growth make it a popular target in cancer research. Fitzgerald Industries supplies a wide range of monoclonal and polyclonal P53 antibodies and proteins ideally suited to research and diagnostic roles. Our high quality P53 antibodies are the ideal choice for use in existing procedures or in the development of new assays.
Some of our most popular p53 antibodies include:
p53 antibody - This monoclonal p53 antibody clone AF2C1 is purified by ammonium sulfate precipitation and is validated for use in ELISA, Immunoprecipitation and Western blot applications, as shown below.
p53 antibody - This purified polyclonal p53 antibody is an excellent choice for use in ELISA assays and Western Blotting.
p53 antibody (HRP) - This polyclonal p53 antibody is conjugated to a HRP tag offering excellent results in ELISA and Western Blot. p53 antibody (FITC) and p53 antibody (biotin) conjugated p53 antibodies are also available.