APAF1 antibody (70R-13842)

Affinity purified Rabbit polyclonal APAF 1 antibody

Synonyms Polyclonal APAF1 antibody, Anti-APAF1 antibody, APAF-1 antibody, Apoptotic protease activating factor 1 antibody, APAF 1, APAF-1, APAF 1 antibody, APAF1, APAF-1 antibody
Applications IHC-P, WB
Immunogen APAF1 antibody was raised in Rabbit using a synthetic peptide corresponding to a sequence at the N-terminal of human APAF1, identical to the related Rabbit sequence, and different from the related rat sequence by one amino acid, as the immunogen

Images

Immunohistochemical staining using APAF1 antibody (70R-13842)

Immunohistochemistry of paraffin-embedded section of Rat Brain Tissue

Specifications

Host Rabbit
Isotype IgG
Method of Purification APAF1 antibody was purified by affinity chromatography
Form & Buffer Supplied in lyophilized form

Usage & Assay Information

Usage Recommendations Optimal conditions to be determined by the end user

Storage & Safety

Storage Store at 4 deg C for short term storage. For long term storage aliquot and store at -20 deg C, avoid repeated freeze/thaw cycles.

General Information

Biological Significance During apoptosis, APAF 1 (apoptosis protease activating factor 1) binds to Cytochrome C (APAF 2), a reaction that requires dATP, and this leads to the formation of a large multimeric complex. The complex recruits pro caspase 9, and activates caspase 9 (APAF 3). Activated caspase 9 in turn cleaves and activates caspase 3, one of the proteases responsible for the proteolytic cleavage of many key proteins in apoptosis. APAF 1 is ubiquitously expressed in human tissues.

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Images

  • <div><font face=Calibri size=2>Immunohistochemical staining using APAF1 antibody (70R-13842)</font></div>     | Immunohistochemistry of paraffin-embedded section of Rat Brain Tissue
  • <div><font face=Calibri size=2>Western Blot analysis using APAF1 antibody (70R-13842)</font></div>     | Western Blot using HT1080 Cell Lysate

Availability: In stock

Price: €220.86
Size: 100 ug
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