APE1 antibody (70R-12483)
Affinity purified Rabbit polyclonal APE1 antibody
Overview
Overview
| Synonyms | Polyclonal APE1 antibody, Anti-APE1 antibody, APEX antibody, apurinic-apyrimidinic endonuclease 1 antibody, APE-1, deoxyribonuclease (apurinic or apyrimidinic) antibody, apurinic/apyrimidinic (abasic) endonuclease antibody, APE1 antibody, APEX nuclease (multifunctional DNA repair enzyme) 1 antibody, AP lyase antibody, DNA-(apurinic or apyrimidinic site) lyase antibody, APEN antibody, redox factor-1 antibody, APE 1, APE antibody, APE-1 antibody, protein REF-1 antibody, APE1, AP endonuclease class I antibody, REF1 antibody, HAP1 antibody, APEX1 antibody, APE 1 antibody, APX antibody |
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| Cross Reactivity | Human |
| Applications | ICC, IF, WB |
| Immunogen | APE1 antibody was raised in rabbit using a synthetic peptide corresponding to a region within amino acids 1 and 45 of APE1 |
Images
Specifications
| Host | Rabbit |
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| Isotype | IgG |
| Method of Purification | APE1 antibody was purified by Protein A chromatography |
| Molecular Weight | 36 kDa |
| Form & Buffer | Supplied as a concentrated soloution containing 0.1M Tris, 0.1M Glycine, 10% Glycerol (pH 7.0). 0.01% Thimerosal was added as a preservative. |
| Concentration | 5.04 mg/ml |
Usage & Assay Information
| Usage Recommendations | IF:1:100-1:200, WB: 1:500-1:3000 |
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Storage & Safety
| Storage | Store at 4 deg C for short term storage. Aliquot and store at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles. |
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General Information
| Biological Significance | Apurinic/apyrimidinic (AP) sites occur frequently in DNA molecules by spontaneous hydrolysis, by DNA damaging agents or by DNA glycosylases that remove specific abnormal bases. AP sites are pre-mutagenic lesions that can prevent normal DNA replication so the cell contains systems to identify and repair such sites. Class II AP endonucleases cleave the phosphodiester backbone 5' to the AP site. |
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