Apg5 antibody (70R-12163)
Rabbit polyclonal Apg5 antibody
Overview
Overview
| Synonyms | Polyclonal Apg5 antibody, anti-Apg5 antibody, atg-5 antibody, Apoptosis-specific protein antibody, Apg-5, autophagy protein antibody, Apg 5 antibody, Apg5, apg-5 antibody, Apg 5, Autophagy protein 5 antibody, Apg-5 antibody, APG5-like antibody, hAPG5 antibody |
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| Cross Reactivity | Human, Mouse, Rat, Pig, Bovine |
| Applications | WB |
| Immunogen | Apg5 antibody was raised in Rabbit using synthetic peptide corresponding to residues surrounding amino acid 226 of rat Apg5 as the immunogen. |
| Assay Information | Apg5 Blocking Peptide, catalog no. 33R-10975, is also available for use as a blocking control in assays to test for specificity of this Apg5 antibody |
Images
Western Blot analysis using Apg5 antibody (70R-12163)
Western blot analysi s of Apg5/Atg5 in Jurkat cell lysate.
Specifications
| Host | Rabbit |
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| Isotype | IgG |
| Method of Purification | Apg5 antibody was purified by affinity chromatography |
| Form & Buffer | Supplied in PBS buffer containing 30% glycerol, 0.5% BSA and 0.01% thimerosal |
| Concentration | 500 ug/ml |
Usage & Assay Information
| Usage Recommendations | WB: 0.5-4 ug/ml |
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Storage & Safety
| Storage | Store at 4 deg C for short term storage. Aliquot and store at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles. |
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General Information
| Biological Significance | Autophagy, the process of bulk degradation of cellular proteins through an autophagosomic-lysosomal pathway is important for normal growth control and may be defective in tumor cells. It is involved in the preservation of cellular nutrients under starvation conditions as well as the normal turnover of cytosolic components. An ubiquitin like conjugation system is involve in the formation of autophagosome where by Atg12 is covanletly bound to Apg5/ATG5. The conjugation is mediated by the ubiquitin-E1-like enzyme Atg7 and thE2-like enzyme Atg10. |
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