APP antibody (10R-1097)

Mouse monoclonal APP antibody

Synonyms Monoclonal APP antibody, Anti-APP antibody, isoform antibody, peptidase nexin-II antibody, amyloid beta (A4) precursor protein antibody, amyloid beta A4 protein precursor antibody, Alzheimer disease antibody
Specificity Human
Cross Reactivity Human, Mouse
Applications ELISA, WB
Immunogen APP antibody was raised in mouse using recombinant human APP (18-289aa) purified from E. coli as the immunogen.

Specifications

Host Mouse
Clone J4H9
Isotype IgG2b kappa
Source Anti-human APP antibody, clone J4H9, is derived from hybridization of mouse F0 myeloma cells with spleen cells from BALB/c mice immunized with a recombinant human APP protein.
Method of Purification APP antibody was purified by protein-G affinity chromatography
Form & Buffer Supplied as a liquid in PBS, pH 7.4, with 0.1% NaN3.
Concentration 1 mg/ml

Usage & Assay Information

Usage Recommendations WB: 1:1000-1:2,000

Storage & Safety

Storage Store at 4 deg C for short term storage. Aliquot and store at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles.

General Information

Biological Significance Amyloid precursor protein (APP) is the precursor molecule whose proteolysis generates amyloid beta, a 39- to 42- amino acid peptide and this amyloid fibrillar form is the primary component of amyloid plaques found in the brains of Alzheimer?s disease patients. APP is an integral membrane protein that is phosphorylated in the cytoplasmic and extracellular domains. It has been reported that cell-surface APP plays a role in neurite extension of primary cultured hippocampal neurons. The large extracellular domain of APP is also reported to bind extracellular matrix molecules such as heparin, laminin, and collagen, which can mediate cell adhesion and neurite outgrowth. Abnormal regulation of the metabolism of APP may contribute to the deposition of plaques.

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Availability: In stock

Price: €249.33
Size: 100 ul
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