APRIL antibody (70R-AR012)

Affinity purified Rabbit polyclonal APRIL antibody

Synonyms Polyclonal APRIL antibody, Anti-APRIL antibody, TRDL-1 alpha antibody, TNFSF13 antibody, A Proliferating-inducing Ligand antibody
Specificity Human APRIL
Cross Reactivity To be determined by end-user
Applications ELISA, Inhibition, WB
Immunogen APRIL antibody was raised in rabbit using highly pure recombinant human APRIL as the immunogen.

Specifications

Host Rabbit
Molecular Weight 21.9 kDa (predicted detection band MW)
Form & Buffer Lyophilized from PBS, pH 7.2.

Usage & Assay Information

Usage Recommendations Optimal conditions to be determined by end user

Storage & Safety

Storage Store at -20 deg C until reconstitution. Following reconstitution product may be stored at 4 deg C in the short term. For long term storage aliquot and freeze at -20 deg C. Avoid repeated freeze/thaw cycles.

General Information

Biological Significance APRIL, a member of the TNF superfamily, is expressed in monocytes, macrophages, certain transformed cell lines, certain cancers of colon, and lymphoid tissues. APRIL, along with another TNF family member, BAFF, compete for two receptors, TACI and BCMA. APRIL has the ability to stimulate proliferation of various tumor cell lines including Jurkat T cells and MCF-7 carcinoma cells. Like BAFF, APRIL also stimulates the proliferation of B and T cells. The human APRIL gene codes for at least four alternatively spliced transcriptional variants, which give rise to different isoforms of the APRIL precursor protein. All isoforms can be cleaved by the protease, furin, to release a soluble C-terminal fragment, which comprises the TNF like receptor binding of the APRIL precursor.

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Availability: In stock

Price: €211.69
Size: 50 ug
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