APRIL protein (30R-AA022)

Purified recombinantMouse APRIL protein

Synonyms A Proliferating-inducing Ligand protein, TRDL-1 alpha protein, TNFSF13 protein, TRDL-1a protein
Species Human
Protein Type Recombinant
Applications User optimized

Specifications

Residues Region of APRIL protein corresponding to amino acids MRREVSRLQR SGGPSQKQGE RPWQSLWEQS PDVLEAWKDG AKSRRRRAVL TQKHKKKHSV LHLVPVNITS KDSDVTEVMW QPVLRRGRGL EAQGDIVRVW DTGIYLLYSQ VLFHDVTFTM GQVVSREGQG RRETLFRCIR SMPSDPDRAY NSCYSAGVFH LHQGDIITVK IPRANAKLSL SPHGTFLGFV KL.
Expression System E.coli
Grade & Purity > 98% pure
Molecular Weight 21.9 kDa
Form & Buffer Lyophilized from 10mM NaC2H3O2, pH 5.0, with 100mM Arginine. Restore in water to a concentration of 0.1 - 1.0 mg/ml.

Usage & Assay Information

Bioactivity Measured by its ability to induce cell proliferation of activated T cells.

Storage & Safety

Storage Store at 4 deg C until reconstitution. Following reconstitution aliquot and freeze at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles.

General Information

Biological Significance APRIL, a member of the TNF superfamily, is expressed in monocytes, macrophages, certain transformed cell lines, certain cancers of colon, and lymphoid tissues. APRIL, along with another TNF family member, BAFF, compete for two receptors, TACI and BCMA. APRIL has the ability to stimulate proliferation of various tumor cell lines including Jurkat T cells and MCF-7 carcinoma cells. Like BAFF, APRIL also stimulates the proliferation of B and T cells. The human APRIL gene codes for at least four alternatively spliced transcriptional variants, which give rise to different isoforms of the APRIL precursor protein. All isoforms can be cleaved by the protease, furin, to release a soluble C-terminal fragment, which comprises the TNF like receptor binding of the APRIL precursor.

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Availability: In stock

Price: €211.69
Size: 20 ug
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