Aprotinin protein (30R-2675)
Purified native Bovine Aprotinin protein
Overview
Overview
| Synonyms | Aprotinin protein, BPI protein, AP protein, Pancreatic trypsin inhibitor protein, BPTI protein, Basic protease inhibitor protein |
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| Species | Bovine |
| Protein Type | Native |
Specifications
| Source | Bovine Lung |
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| Grade & Purity | > 98% pure |
| Method of Purification | Aprotinin protein was purified using a a proprietary chromatographic technique. |
| Molecular Weight | 6.5 kDa |
| Form & Buffer | Supplied in lyophilized form with no additives |
Storage & Safety
| Storage | Store at 4 deg C for short term storage. Aliquot and store at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles. |
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| Endotoxin Levels | <0.1 ng/ug |
General Information
| Biological Significance | Aprotinin inhibits the activity of several proteolytic enzymes such as chymotrypsin, kallikrein, plasmin and trypsin. It is present in blood and in most tissues, with a high concentration in lung, inhibits pro-inflammatory cytokine release and maintains glycoprotein homeostasis. In platelets, aprotinin reduces glycoprotein loss, while in granulocytes it prevents the expression of pro-inflammatory adhesive glycoproteins. Aprotinin is a natural proteinase inhibitor polypeptide consisting of fifty-eight amino acids arranged in a single polypeptide chain, cross-linked by three disulfide bridges and having a molecular mass of 6512 Daltons. Aprotinin is purified by proprietary chromatographic techniques. |
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