ARL6 protein (His tag) (80R-1840)
Purified recombinant ARL6 protein
|Synonyms||ADP-ribosylation factor-like protein 6 protein, BBS3 protein, ARL-6 protein, ARL6, RP55 protein, ARL-6, MGC32934 protein, ARL 6 protein, ARL 6|
Coomassie Blue stained SDS-PAGE of ARL6 protein (His tag) (80R-1840)
Figure annotation denotes ug of protein loaded and % gel used.
|Residues||1-186 amino acids: MGSSHHHHHH SSGLVPRGSH MGLLDRLSVL LGLKKKEVHV LCLGLDNSGK TTIINKLKPS NAQSQNILPT IGFSIEKFKS SSLSFTVFDM SGQGRYRNLW EHYYKEGQAI IFVIDSSDRL RMVVAKEELD TLLNHPDIKH RRIPILFFAN KMDLRDAVTS VKVSQLLCLE NIKDKPWHIC ASDAIKGEGL QEGVDWLQDQ IQTVKT|
|Grade & Purity||> 90% pure|
|Molecular Weight||23.2 kDa (206aa), confirmed by MALDI-TOF|
|Form & Buffer||Supplied as a liquid in 20mM Tris-HCl buffer, pH 8.0, containing 20% glycerol, 0.2M NaCl and 5mM DTT.|
Storage & Safety
|Storage||Store at 4 deg C for short term storage (1/2 weeks). Aliquot and store at -20 deg C or - 70 deg C for long term storage. Avoid repeated freeze/thaw cycles.|
|Biological Significance||ARL6, also known ADP-ribosylation factor-like protein 6, belongs to the ARF family of GTP-binding proteins. This protein is known to play essential roles in modulating membrane trafficking and cytoskeletal functions. Mutation in ARL6 causes Bardet-Biedl syndrome (BBS3). BBS is a pleiotropic genetic disorder characterized by obesity, photoreceptor degeneration, polydactyly, hypogenitalism, renal abnor-malities and developmental delay. Recombinant human ARL6 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography.|
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