ASF1A protein (His tag) (80R-1135)
Purified recombinant Human ASF1A protein
|Synonyms||ASF1 anti-silencing function 1 homolog A Anti silencing function 1A protein, hAsf1a protein, HSPC146 protein, , ASF1 anti-silencing function 1 homolog A protein, ASFA-1, hCIA protein, CGI-98 protein, ASFA 1 protein, CIA protein, ASF1A, ASFA-1 protein, CGI 98 protein, CCG1 interacting factor A protein, Histone chaperone ASF1A protein, ASF1 anti silencing function 1 homolog A protein, ASFA 1, Histone chaperone ASF1A protein, CCG1-interacting factor A (CIA) protein, hAsf1 protein|
Coomassie Blue stained SDS-PAGE of ASF1A protein (His tag) (80R-1135)
Figure annotation denotes ug of protein loaded and % gel used.
|Residues||1-204 amino acids: MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSMAKV QVNNVVVLDN PSPFYNPFQF EITFECIEDL SEDLEWKIIY VGSAESEEYD QVLDSVLVGP VPAGRHMFVF QADAPNPGLI PDADAVGVTV VLITCTYRGQ EFIRVGYYVN NEYTETELRE NPPVKPDFSK LQRNILASNP RVTRFHINWE DNTEKLEDAE SSNPNLQSLL STDALPSASK GWSTSENSLN VMLESHMDCM|
|Grade & Purity||> 90% pure|
|Molecular Weight||27 kDa (240aa), confirmed by MALDI-TOF.|
|Form & Buffer||Supplied as a liquid in 20mM Tris-HCl buffer, pH 8.0, containing 1mM DTT, and 10% glycerol.|
Storage & Safety
|Storage||Store at 4 deg C for short term storage (1/2 weeks). Aliquot and store at -20 deg C or - 70 deg C for long term storage. Avoid repeated freeze/thaw cycles.|
|Endotoxin Levels||< 1.0 EU per ug of protein (determined by LAL method)|
|Biological Significance||ASF1 anti-silencing function 1 homolog A, also known as ASF1A, belongs to H3/H4 family of histone chaperone proteins. ASF1A protein interacts with histones H3 and H4, and functions together with a chromatin assembly factor during DNA replication and repair. Deletion of ASF1A in yeast and Drosophila confers sensitivity to various DNA damaging agents and inhibitors of DNA replication, increases genomic instability and sister chromatid exchange, and activates the DNA damage checkpoint. Recombinant human ASF1A, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography.|
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