Ataxin 3 protein (30R-1344)

Purified recombinant Human Ataxin 3 protein

Synonyms Machado-Joseph disease protein 1 homolog protein, Machado Joseph disease protein, AT3 protein, JOS protein, MJD1 protein, MJD gene protein, Machado Joseph disease protein 1 protein, EC 3.4.22. protein, ATXN3 protein, , Spinocerebellar ataxia type 3 protein protein, Rsca3 protein, MJD protein, Josephin protein, ATX3 protein, ATXN3 protein, SCA3 protein, Ataxin 3 protein, SCA3 gene protein
Species Human
Protein Type Recombinant
Applications SDS-PAGE

Specifications

Residues 1-370 amino acids: MESIFHEKQE GSLCAQHCLN NLLQGEYFSP VELSSIAHQL DEEERMRMAE GGVTSEDYRT FLQQPSGNMD DSGFFSIQVI SNALKVWGLE LILFNSPEYQ RLRIDPINER SFICNYKEHW FTVRKLGKQW FNLNSLLTGP ELISDTYLAL FLAQLQQEGY SIFVVKGDLP DCEADQLLQM IRVQQMHRPK LIGEELAQLK EQRVHKTDLE RVLEANDGSG MLDEDEEDLQ RALALSRQEI DMEDEEADLR RAIQLSMQGS SRNISQDMTQ TSGTNLTSEE LRKRREAYFE KQQQKQQQQQ QQQQQQQQQQ QQQQGDLSGQ SSHPCERPAT SSGALGSDLG DAMSEEDMLQ AAVTMSLETV RNDLKTEGKK
Expression System E.coli
Grade & Purity > 90% pure
Molecular Weight 42.4 kDa (370aa), confirmed by MALDI-TOF.
Form & Buffer Supplied as a liquid in 20mM Tris-HCl buffer, pH 7.5, containing 2mM DTT, 50mM NaCl, and 10% glycerol.
Concentration 1 mg/ml

Storage & Safety

Storage Store at 4 deg C for short term storage (1/2 weeks). Aliquot and store at -20 deg C or - 70 deg C for long term storage. Avoid repeated freeze/thaw cycles.
Endotoxin Levels < 1.0 EU per ug of protein (determined by LAL method)

General Information

Biological Significance Ataxin 3 is also known as Machado-Joseph disease protein 1. Machado?Joseph disease is one of several hereditary autosomal dominant neurodegenerative disorders. This protein contains trinucleotide CAG repeats in the coding region, and the expansion of these repeats from the normal 13-36 to 68-79 is the cause of Machado-Joseph disease. Ataxin 3 interacts with the major histone acetyltransferases cAMP-response-element binding protein (CREB)-binding protein, p300, and p300/CREB-binding protein-associated factor and inhibits transcription by these coactivators. Also, ataxin-3 is a proteasome-associated factor that mediates the degradation of ubiquitinated proteins. Recombinant human Ataxin-3 was expressed in E. coli and purified by using conventional chromatography.

References
Add a Paper

Sorry, but there are no references currently for this product.

Reviews

You need to be logged in to write a review. Please login here

Sorry there are currently no reviews for this product

Availability: In stock

Price: €239.92
Size: 50 ug
OR
Shipping
View Our Distributors