ATOX1 protein (His tag) (80R-1226)
Purified recombinant Human ATOX1 protein
|Synonyms||Metal transport protein., Copper transport protein protein, Antioxidant protein 1 protein, Copper transport protein ATOX1 ATX1 protein, ATOX-1, HAH1 protein, ATX1 protein, ATOX-1 protein, ATOX1, ATOX 1, ATOX 1 protein|
Coomassie Blue stained SDS-PAGE of ATOX1 protein (His tag) (80R-1226)
Figure annotation denotes ug of protein loaded and % gel used.
|Residues||1-68 amino acids: MGSSHHHHHH SSGLVPRGSH MPKHEFSVDM TCGGCAEAVS RVLNKLGGVK YDIDLPNKKV CIESEHSMDT LLATLKKTGK TVSYLGLE|
|Grade & Purity||> 95% pure|
|Molecular Weight||9.5 kDa (88aa), confirmed by MALDI-TOF.|
|Form & Buffer||Supplied as a liquid in 20mM Tris-HCl buffer, pH 8.0, containing 1mM DTT and 10% glycerol.|
Storage & Safety
|Storage||Store at 4 deg C for short term storage (1/2 weeks). Aliquot and store at -20 deg C or - 70 deg C for long term storage. Avoid repeated freeze/thaw cycles.|
|Biological Significance||Copper transport protein ATOX1, also known as HAH1, a metal transport protein that belongs to the ATX1 family. ATOX1 is involved in cellular antioxidant defense and can bind and deliver cytosolic copper to the copper ATPase proteins. This protein also functions as an antioxidant against superoxide and hydrogen peroxide, and therefore, may play a significant role in cancer carcinogenesis. Because of its cytogenetic location, this gene represents a candidate gene for 5q-syndrome. Recombinant human ATOX1, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.|
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