Aurora Kinase B protein (His tag) (80R-1199)
Purified recombinant Human Aurora Kinase B protein
|Synonyms||STK5 protein, STK1 protein, aurkb-sv1 protein, ARK2 protein, AIK2 protein, Aurora kinase B protein, Aurora 1 protein, AIM1 protein, aurkb-sv2 protein, , AURKB protein, STK12 protein, Serine/threonine protein kinase 12 protein, AIM1 protein, Aurora and Ipl1 like midbody associated protein 1 protein, AurB protein, aurkb protein, Aurora related kinase 2 protein, IPL1 protein, Aurora-B protein, Aurora/IPL1 related kinase 2 protein, Serine/threonine-protein kinase 12 protein, Serine/theronine kinase 12 protein|
Coomassie Blue stained SDS-PAGE of Aurora Kinase B protein (His tag) (80R-1199)
Figure annotation denotes ug of protein loaded and % gel used.
|Residues||1-344 amino acids: MGSSHHHHHH SSGLVPRGSH MAQKENSYPW PYGRQTAPSG LSTLPQRVLR KEPVTPSALV LMSRSNVQPT AAPGQKVMEN SSGTPDILTR HFTIDDFEIG RPLGKGKFGN VYLAREKKSH FIVALKVLFK SQIEKEGVEH QLRREIEIQA HLHHPNILRL YNYFYDRRRI YLILEYAPRG ELYKELQKSC TFDEQRTATI MEELADALMY CHGKKVIHRD IKPENLLLGL KGELKIADFG WSVHAPSLRR KTMCGTLDYL PPEMIEGRMH NEKVDLWCIG VLCYELLVGN PPFESASHNE TYRRIVKVDL KFPASVPMGA QDLISKLLRH NPSERLPLAQ VSAHPWVRAN SRRVLPPSAL QSVA|
|Grade & Purity||> 90% pure|
|Molecular Weight||41.4 kDa (364aa), confirmed by MALDI-TOF.|
|Form & Buffer||Supplied as a liquid in 20mM Tris-HCl buffer, pH 8.0, containing 0.5mM DTT, 20% glycerol, 0.1mM EDTA, 0.1mM EGTA, 0.1M NaCl, and 0.1mM PMSF.|
Storage & Safety
|Storage||Store at 4 deg C for short term storage (1/2 weeks). Aliquot and store at -20 deg C or - 70 deg C for long term storage. Avoid repeated freeze/thaw cycles.|
|Biological Significance||Aurora Kinase B is a member of a family of mitotic serine/threonine kinases. Aurora Kinase B associates with chromosomes during prophase prior to relocalizing to the spindle at anaphase. Aurora Kinase B regulates chromosome segregation through the control of microtubule-kinetochore attachment and cytokinesis. Expression of Aurora Kinase B during the G2/M phase transition is tightly coordinated with histone H3 phosphorylation, while overexpression in many kinds of cancers. Recombinant human Aurora Kinase B, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.|
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