B7DC antibody (10R-6698)

Rat monoclonal B7DC antibody

Synonyms Monoclonal B7DC antibody, Anti-B7DC antibody, PD-L2 antibody, BDC 7, PDL2 antibody, BDC-7, BDC 7 antibody, B7DC, BDC-7 antibody, B7DC antibody, PDL-2 antibody
Specificity Mouse
Applications Functional Assay
Assay Information The bioactivity of this protein was determined by transmigration assay of human T lymphocytes, with maximum chemotaxis observed at 100-200 ng/ml. The ED50 for this effect is less than or equal to 50 ng/ml, which corresponds to a specific activity of greater than or equal to 2 x 10e4 Units/mg.

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Specifications

Host Rat
Clone 122
Isotype IgG2a kappa
Method of Purification B7DC antibody was purified by affinity chromatography.
Form & Buffer Supplied in aqueous buffer with 0.09% sodium azide, may contain carrier protein/stabilizer.
Concentration 100 ug/ml

Storage & Safety

Storage Store at 2-8 deg C. Do not freeze. Protect from light.

General Information

Biological Significance The 122 monoclonal antibody reacts with mouse B7-DC, also known as PD-L2. B7-DC, a recently identified member of the B7 family, has a predicted molecular weight of approximately 25 kDa and belongs to the Ig superfamily. The mouse B7-DC has a short cytoplasmic tail. B7-DC is primarily expressed by subpopulations of dendritic cells and monocytes/macrophages in the mouse. Although B7-DC has structural and sequence similarities to the B7 family, it does not bind CD28/CTLA-4, rather it is a ligand for PD-1. The interactions between PD-1 and B7-DC/PD-L2 have been reported to be involved in costimulation or suppression of T cell proliferation depending on state of cellular activation. 122 has been demonstrated to block binding of TY25, another mAb specific for mouse B7-DC.

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Availability: In stock

Price: €134.97

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Price: €134.97
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