B7DC antibody (10R-6698)
Rat monoclonal B7DC antibody
Overview
Overview
| Synonyms | Monoclonal B7DC antibody, Anti-B7DC antibody, PD-L2 antibody, BDC 7, PDL2 antibody, BDC-7, BDC 7 antibody, B7DC, BDC-7 antibody, B7DC antibody, PDL-2 antibody |
|---|---|
| Specificity | Mouse |
| Applications | Functional Assay |
| Assay Information | The bioactivity of this protein was determined by transmigration assay of human T lymphocytes, with maximum chemotaxis observed at 100-200 ng/ml. The ED50 for this effect is less than or equal to 50 ng/ml, which corresponds to a specific activity of greater than or equal to 2 x 10e4 Units/mg. |
Specifications
| Host | Rat |
|---|---|
| Clone | 122 |
| Isotype | IgG2a kappa |
| Method of Purification | B7DC antibody was purified by affinity chromatography. |
| Form & Buffer | Supplied in aqueous buffer with 0.09% sodium azide, may contain carrier protein/stabilizer. |
| Concentration | 100 ug/ml |
Storage & Safety
| Storage | Store at 2-8 deg C. Do not freeze. Protect from light. |
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General Information
| Biological Significance | The 122 monoclonal antibody reacts with mouse B7-DC, also known as PD-L2. B7-DC, a recently identified member of the B7 family, has a predicted molecular weight of approximately 25 kDa and belongs to the Ig superfamily. The mouse B7-DC has a short cytoplasmic tail. B7-DC is primarily expressed by subpopulations of dendritic cells and monocytes/macrophages in the mouse. Although B7-DC has structural and sequence similarities to the B7 family, it does not bind CD28/CTLA-4, rather it is a ligand for PD-1. The interactions between PD-1 and B7-DC/PD-L2 have been reported to be involved in costimulation or suppression of T cell proliferation depending on state of cellular activation. 122 has been demonstrated to block binding of TY25, another mAb specific for mouse B7-DC. |
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