Store at -20 deg C. For long-term storage, aliquot and freeze at -70 deg C. Avoid repeated freeze/thaw cycles.
General Information
Biological Significance
The Bcl 2 (B cell leukemia/lymphoma 2) family proteins function to either inhibit (Bcl 2 and Bcl XL) or promote (Bax and Bad) apoptosis. Similar to other family member, Bad also exhibits sequence homology to Bcl 2. Bad can selectively dimerize with Bcl xL and Bcl 2, but not with Bax, Bcl xs, Mcl 1, or itself. In mammalian cells, Bad binds more strongly to Bcl xL than Bcl 2. This may explain why Bad reverse the death repressor activity of Bcl xL, but not that of Bcl 2