Bad antibody (20R-1434)

Rabbit polyclonal Bad antibody

Synonyms Polyclonal Bad antibody, Anti-Bad antibody
Cross Reactivity Human, Mouse, Rat, Monkey
Applications IHC, IP, WB
Immunogen Bad antibody was raised in Rabbit using synthetic peptide surrounding amino acid 115 of mouse Bad as the immunogen.

Specifications

Host Rabbit
Isotype IgG
Method of Purification Bad antibody was purified by antigen affinity purification.
Form & Buffer Supplied in PBS buffer, pH 7.2, containing 50% glycerol, 1% BSA, 0.02% thimerosal.
Concentration 500 ug/ml

Usage & Assay Information

Usage Recommendations IHC: 20-40 ug/ml, IP: 4-8 ug/ml, WB: 1-2 ug/ml

Storage & Safety

Storage Store at -20 deg C. For long-term storage, aliquot and freeze at -70 deg C. Avoid repeated freeze/thaw cycles.

General Information

Biological Significance The Bcl 2 (B cell leukemia/lymphoma 2) family proteins function to either inhibit (Bcl 2 and Bcl XL) or promote (Bax and Bad) apoptosis. Similar to other family member, Bad also exhibits sequence homology to Bcl 2. Bad can selectively dimerize with Bcl xL and Bcl 2, but not with Bax, Bcl xs, Mcl 1, or itself. In mammalian cells, Bad binds more strongly to Bcl xL than Bcl 2. This may explain why Bad reverse the death repressor activity of Bcl xL, but not that of Bcl 2

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Availability: In stock

Price: €486.71
Size: 100 ug
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