BAFF protein (30R-2219)

Purified recombinant Human BAFF protein

Synonyms B-cell activating factor protein, TALL-1 protein, BLYS protein, TALL1 protein, THANK protein, TNFSF13B protein
Specificity Human
Species Human
Protein Type Recombinant
Applications Functional Assay
Assay Information The ED50, as determined by the dose-dependent stimulation of mouse 7TD1 cell proliferation, is 1.9 ng/ml.

Specifications

Expression System E.coli
Grade & Purity > 90% pure
Method of Purification BAFF protein was purified by affinity chromatography.
Molecular Weight 17.2 kDa
Form & Buffer Supplied as a sterile liquid with 10 mM phosphate, 150 mM NaCl,1.0% BSA. 0.22 um filtered.
Concentration 100 ug/ml

Usage & Assay Information

Bioactivity The ED50, as determined by a mouse splenocytesurvival assay, is 1.6 ug/ml.

Storage & Safety

Storage Store at -70 deg C or less.
Endotoxin Levels Less than 0.01 ng/ug cytokine as determined by the LAL assay.

General Information

Biological Significance Recombinant human BAFF, also referred to as BlyS, is a type II transmembrane protein of the TNF superfamily. BAFF is found on T cells, macrophages and dendritic cells. BAFF contains a cytoplasmic domain, transmembrane domain and extracellular domain which can be cleaved between amino acid 133 and 134 to produce a soluble form detectable in serum. Receptors for BAFF include TACI, BAMBI and BAFFR. BAFF/BLyS is a B lymphocyte stimulatory molecule it induces B cell proliferation and immunoglobulin secretion. In addition BAFF can provide a co-stimulation signal to T lymphocytes. Elevated levels of BAFF has been implicated in the pathogenesis of some autoimmune diseases B cell diseases such as systemic lupus erythaematosus. Human and mouse BAFF share 86% amino acid sequence identity.

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