BCAS2 protein (His tag) (80R-1672)
Purified recombinant Human BCAS2 protein
|Synonyms||SPF27, BCAS-2, Snt307 protein, BCAS 2, BCAS2, BCAS-2 protein, DAM1 protein, BCAS 2 protein, pre-mRNA-splicing factor SPF27 protein|
Coomassie Blue stained SDS-PAGE of BCAS2 protein (His tag) (80R-1672)
Figure annotation denotes ug of protein loaded and % gel used.
|Residues||1-225 amino acids: MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSMAGT GLVAGEVVVD ALPYFDQGYE APGVREAAAA LVEEETRRYR PTKNYLSYLT APDYSAFETD IMRNEFERLA ARQPIELLSM KRYELPAPSS GQKNDITAWQ ECVNNSMAQL EHQAVRIENL ELMSQHGCNA WKVYNENLVH MIEHAQKELQ KLRKHIQDLN WQRKNMQLTA GSKLREMESN WVSLVSKNYE IERTIVQLEN EIYQIKQQHG EANKENIRQD F|
|Grade & Purity||> 85% pure|
|Molecular Weight||30.3 kDa (261aa), confirmed by MALDI-TOF|
|Form & Buffer||Supplied as a liquid in 20mM Tris-HCl buffer, pH 8.0, containing 20% glycerol, 5mM DTT and 0.2M NaCl.|
Storage & Safety
|Storage||Store at 4 deg C for short term storage (1/2 weeks). Aliquot and store at -20 deg C or - 70 deg C for long term storage. Avoid repeated freeze/thaw cycles.|
|Biological Significance||BCAS2, also known as pre-mRNA-splicing factor SPF27, is a ubiquitously expressed nuclear protein that was originally identified as being overexpressed in various breast cancer cell lines. It is now known to be a component of the spliceosome, participating in the removal of introns from mRNA precursors. BCAS2 specifically interacts (in a ligand-independent manner) with thyroid hormone receptor, estrogen receptor, progesterone receptor and peroxisome proliferator-activated receptor. This protein functions as an ER co-activator and is capable of enhancing ER-mediated transcription. This suggests that BCAS2 is involved in the development of breast cancer. Recombinant human BCAS2 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.|
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