beta Amyloid antibody (10R-A124a)
Mouse monoclonal beta Amyloid antibody
Overview
Overview
| Synonyms | Monoclonal beta Amyloid antibody, Anti-beta Amyloid antibody, Alzheimer Precursor Protein A4 antibody, Ab antibody, Amyloid beta antibody, APP-A4 antibody, Abeta antibody, Amyloid Plaque antibody |
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| Cross Reactivity | Dog, fish, human, monkey, mouse, pig, Rat |
| Applications | IF, IHC, WB |
| Immunogen | Beta amyloid antibody was raised in mouse using purified recombinant alzheimer precursor A4 fusion protein as the immunogen. |
Images
Immunohistochemical staining using beta Amyloid antibody (10R-A124a)
Amyloid (Abeta) staining on Alzheimer’s Disease-Hypothalamus (left). Tissue pretreated with Citrate, pH 6.0. beta Amyloid antibody diluted to 1:80. Immunoreactivity is seen as cerebral vascular amyloid deposition in the walls of blood vessels (brown). Negative Control staining on Alzheimer’s Disease-Hypothalamus (right). Tissue pretreated with Citrate, pH 6.0.
Specifications
| Host | Mouse |
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| Clone | 22C11 |
| Isotype | IgG1 |
| Form & Buffer | 20mM PO4 buffer, with 0.25M NaCl, and 0.1% NaN3. |
| Concentration | 1.0 mg/ml |
Usage & Assay Information
| Usage Recommendations | IHC: 5-10 ug/ml, WB: 10 ug/ml |
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Storage & Safety
| Storage | Store at 4 deg C. |
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| Biohazard Information | This product contains sodium azide as preservative. Although the amount of sodium azide is very small appropriate care must be taken when handling. |
General Information
| Biological Significance | Deposits of amyloid protein in senile plaques near nerve processes are found in the brains of aged humans and cases of Alzheimer's Disease. The principle component of this extracellular amyloid is beta A4, a 4 kDa peptide derived from a larger amyloid precursor protein (APP), which is widely expressed in the brain and body. The creation, transport and function of these proteins is currently an active area of research. |
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