BMP2 protein (30R-2210)
Purified recombinant Human BMP2 protein
Overview
Overview
| Synonyms | BMP 2, BMP-2 protein, Bone Morphogenetic Protein 2 protein, BMP 2 protein, BMP-2, BMP2 |
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| Species | Human |
| Protein Type | Recombinant |
| Applications | Functional Assay |
| Assay Information | The ED50 of this protein, as measured by CTLL-2 proliferation assay, is less than or equal to 175 pg/ml. This corresponds to a specific activity of greater than or equal to 5.7 x 10e6 Units/mg. |
Images
Functional Assay using BMP2 protein (30R-2210)
Induction of alkaline phosphatase in C3H/10T1/2 cells by Human BMP2 protein.
Specifications
| Expression System | E.coli |
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| Grade & Purity | > 97% pure |
| Method of Purification | BMP2 protein was purified by affinity chromatography. |
| Molecular Weight | 13 kDa |
| Form & Buffer | Supplied as a sterile liquid with 0.1 M glycine, 1%BSA |
Usage & Assay Information
| Bioactivity | The ED50 of this protein, asdetermined by alkaline phosphataseinduction in C3H/10T1/2 cells, is 0.25-1ug/ml. This corresponds to a specific activity of 4x103 - 1x10^3 Units/mg. |
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Storage & Safety
| Storage | Store at -70 deg C or less. |
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| Endotoxin Levels | Less than 0.01 ng/ug cytokine as determined by the LAL assay. |
General Information
| Biological Significance | BMP-2 is one of fifteen bone morphogenetic proteins belonging to the TGF-beta superfamily. The BMPs were first identified as the active factors in demineralized bone matrix, with transcripts later being discovered in many other types of tissue. They are synthesized as large precursor molecules that must be cleaved into their active form and dimerize in order to exhibit functional activity. These dimers may include two identical or distinct BMP chains. BMP responsiveness appears to be limited to multipotent and immature cells. The BMPs are essential for osteogenesis and organogenesis during embryonic development, and also play a role in fracture and wound healing in adults. |
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