Bordetella pertussis FHA protein (30-1857)

Purified Native Bordetella pertussis FHA protein

Synonyms Bordetella pertussis FHA antigen, Bordetella pertussis filamentous hemagglutinin protein, Filamentous hemagglutinin protein, FHA protein, Bordetella pertussis protein
Species Viral
Protein Type Native

Specifications

Source Purified FHA from B. pertussis
Grade & Purity > 98% pure
Form & Buffer Supplied in 0.05M tris-HCl pH8, 0.5M sodium chloride, 5% sucrose
Concentration 500 ug/ml

Storage & Safety

Storage Store at 4 deg C

General Information

Product Use Bordetella pertussis FHA protein for use in the research laboratory
Biological Significance Pertussis toxin (PT) is a protein-based AB5-type exotoxin produced by the bacterium Bordetella pertussis, which causes whooping cough. PT is involved in the colonization of the respiratory tract and the establishment of infection. Research suggests PT may have a therapeutic role in treating a number of common human ailments, including hypertension, viral inhibition, and autoimmune inhibition.
Implications in Disease Pertussis (or whooping cough) is an infection of the respiratory system characterized by a “whooping” sound when the person breathes in. B. pertussis has the ability to inhibit the function of the host's immune system. The toxin, known as pertussis toxin (or PTx), inhibits G protein coupling that regulates an adenylate cyclase-mediated conversion of ATP to cyclic AMP. The end result is phagocytes convert too much ATP to cyclic AMP, which can cause disturbances in cellular signaling mechanisms, and prevent phagocytes from correctly responding to an infection. The infection occurs mostly in children under the age of one when they are unimmunized, or children with faded immunity, normally around the ages 11 through 18. The signs and symptoms are similar to a common cold: runny nose, sneezing, mild cough, and low-grade fever. The patient becomes most contagious during the catarrhal stage of infection, normally two weeks after the coughing begins.

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Price From: Price: €265.85
Price From: Price: €265.85
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