BST2 protein (His tag) (80R-1875)
Purified recombinant BST2 protein
|Synonyms||CD317 protein, HM1.24 antigen protein, BST 2 protein, BST-2, BST 2, Tetherin protein, BST2, BST-2 protein|
Coomassie Blue stained SDS-PAGE of BST2 protein (His tag) (80R-1875)
Figure annotation denotes ug of protein loaded and % gel used.
|Residues||50-161 amino acids: MGSSHHHHHH SSGLVPRGSH MSEACRDGLR AVMECRNVTH LLQQELTEAQ KGFQDVEAQA ATCNHTVMAL MASLDAEKAQ GQKKVEELEG EITTLNHKLQ DASAEVERLR RENQVLSVRI ADKKYYPSSQ DSS|
|Grade & Purity||> 80% pure|
|Molecular Weight||14.8 kDa (133aa), confirmed by MALDI-TOF|
|Form & Buffer||Supplied as a liquid in 20mM Tris-HCl buffer, pH 8.0, containing 20% glycerol, 0.1M NaCl and 1mM DTT.|
Storage & Safety
|Storage||Store at 4 deg C for short term storage (1/2 weeks). Aliquot and store at -20 deg C or - 70 deg C for long term storage. Avoid repeated freeze/thaw cycles.|
|Biological Significance||BST2, also known as bone marrow stromal antigen 2, is involved in the growth and development of B-cells. BST2 is a human cellular protein which inhibits retrovirus infection by preventing the diffusion of virus particles after budding from infected cells. Initially discovered as an inhibitor to HIV-1 infection in the absence of Vpu, tetherin has also been shown to inhibit the release of other viruses such as the Lassa and Marburg virions. Also, this protein may play a role in B-cell activation in rheumatoid arthritis. Recombinant human BST2 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography.|
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