Store at -20 deg C. For long-term storage, aliquot and freeze at -70 deg C. Avoid repeated freeze/thaw cycles.
General Information
Biological Significance
Extracellular stimuli such as growth factors and UV irradiation stimulate phosphorylation of c Jun at Ser63/73 and activate c Jun dependent transcription. Mutation at Ser63/73 renders c Jun nonresponsive to mitogenic and stress induced signaling pathways. JNK (c jun N terminal Kinase) binds to the N terminal region of c Jun and phosphorylates c Jun at Ser63/73. The activity of JNK is stimulated by the same signals that activate c Jun.