C Peptide antibody (10-2312)
Recombinant Fab monoclonal C Peptide antibody
Overview
Overview
| Synonyms | Monoclonal C Peptide antibody, Anti-C Peptide antibody, Proinsulin C-Peptide, C peptide antibody, Cpeptide antibody, Proinsulin peptide antibody, Connecting peptide antibody, C-peptide antibody |
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| Specificity | Human |
| Cross Reactivity | Sandwich pair does not detect Proinsulin. Individual antibody not tested against Proinsulin |
| Protein Type | Recombinant |
| Applications | ELISA, Luminex Assay |
| Assay Information | C Peptide antibody pair: 10-2311 can be used as the capture antibody with 10-2312 as the detection antibody for detection of human C Peptide in ELISA and Luminex Assay |
Specifications
| Host | Mouse |
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| Clone | M72095 |
| Isotype | IgG1 kappa - Fab fragment |
| Expression System | E.coli |
| Grade & Purity | > 95% pure |
| Method of Purification | C Peptide antibodies screened using Phage Display system. Expressed in and purified from E. coli. |
| Tag/Conjugate | His tag |
| Form & Buffer | Supplied as liquid in 50 mM Potassium Phosphate, 10 mM Boric Acid, 150 mM NaCl, pH 7 |
| Concentration | > 1 mg/ml |
Storage & Safety
| Storage | Store at -20 deg C in small aliquots. Avoid repeated freeze thawing. |
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General Information
| Biological Significance | C Peptide has been shown to bind to the surface of a number of cell types such as neuronal, endothelial, fibroblast and renal tubular, at nanomolar concentrations to a receptor that is likely G-protein-coupled. The signal activates Ca2+-dependent intracellular signaling pathways such as MAPK, PLC?, and PKC, leading to upregulation of a range of transcription factors as well as eNOS and Na+K+ATPase activities. C Peptide antibody was produced as a recombinant Fab monoclonal antibody in a Phage Display system. This anti-C Peptide antibody is used for detection of human C Peptide in ELISA, Luminex Assay. The concentration of the antibody ranges from 1 mg/ml to 25 mg/ml depending on the lot. Recombinant Fab monoclonal antibodies have a number of advantages over standard antibodies including; improved scale up for batch consistency, more efficient binding so less antibody required, more accurate binding meaning fewer conjugation issues, less non specific due to removal of the Fc region, more flexibility for purification and labeling through a C-terminal His tag. |
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