CAB39 protein (His tag) (80R-1380)
Purified recombinant Human CAB39 protein
|Synonyms||CAB 39, MO 25 protein, CAB-39, CGI-66 protein, CAB-39 protein, MO-25 protein, CAB 39 protein, FLJ22682, MO25 protein, Calcium binding protein 39 protein, CAB 39 protein, CAB39, CAB-39 protein|
Coomassie Blue stained SDS-PAGE of CAB39 protein (His tag) (80R-1380)
Figure annotation denotes ug of protein loaded and % gel used.
|Residues||1-341 amino acids: MGSSHHHHHH SSGLVPRGSH MPFPFGKSHK SPADIVKNLK ESMAVLEKQD ISDKKAEKAT EEVSKNLVAM KEILYGTNEK EPQTEAVAQL AQELYNSGLL STLVADLQLI DFEGKKDVAQ IFNNILRRQI GTRTPTVEYI CTQQNILFML LKGYESPEIA LNCGIMLREC IRHEPLAKII LWSEQFYDFF RYVEMSTFDI ASDAFATFKD LLTRHKLLSA EFLEQHYDRF FSEYEKLLHS ENYVTKRQSL KLLGELLLDR HNFTIMTKYI SKPENLKLMM NLLRDKSRNI QFEAFHVFKV FVANPNKTQP ILDILLKNQA KLIEFLSKFQ NDRTEDEQFN DEKTYLVKQI RDLKRPAQQE A|
|Grade & Purity||> 90% pure|
|Molecular Weight||42 kDa (361aa), confirmed by MALDI-TOF|
|Form & Buffer||Supplied as a liquid in 20mM Tris-HCl buffer, pH 8.0, containing 1mM DTT and 10% glycerol.|
Storage & Safety
|Storage||Store at 4 deg C for short term storage (1/2 weeks). Aliquot and store at -20 deg C or - 70 deg C for long term storage. Avoid repeated freeze/thaw cycles.|
|Biological Significance||Calcium binding protein 39, also known as CAB39, is a 40-kDa protein that, together with the STE20-related adaptor-alpha (STRAD alpha) pseudo kinase, forms a regulatory complex capable of stimulating the activity of the LKB1 tumor suppressor protein kinase. Also CAB39 may function as a scaffolding component of the STK11/STRAD complex and regulates STK11 activity and cellular localization. Recombinant human CAB39, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques|
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