Calcineurin A antibody (20R-1444)

Rabbit polyclonal Calcineurin A antibody

Synonyms Polyclonal Calcineurin A antibody, Anti-Calcineurin A antibody, Calcineurin-A antibody
Cross Reactivity Human, Mouse, Rat, Hamster, Rabbit, Bovine
Applications IP, WB
Immunogen Calcineurin A antibody was raised in Rabbit using synthetic peptide corresponding to residues surrounding amino acids 267 of human Calcineurin A as the immunogen.

Specifications

Host Rabbit
Isotype IgG
Method of Purification Calcineurin A antibody was purified by affinity purification.
Form & Buffer Supplied in PBS buffer, pH 7.2, containing 30% glycerol, 0.5% BSA, 0.01% thimerosal.
Concentration 200 ug/ml

Usage & Assay Information

Usage Recommendations IP: 10-20 ug/ml, WB: 1-4 ug/ml

Storage & Safety

Storage Store at -20 deg C. For long-term storage, aliquot and freeze at -70 deg C. Avoid repeated freeze/thaw cycles.

General Information

Biological Significance Calcineurin is a calcium/calmodulin dependent serine/threonine protein phosphatase. The active enzyme is a heterodimer consisting of a catalytic A subunit of 61 kDa and a myristylated regulatory B subunit of 19 kDa that binds calcium. The catalytic A subunit consists of an amino terminal catalytic domain, followed by calmodulin and B subunit binding sites, and a caboxyl terminal autoinhibitory domain. Calnineurin is the target of immunosuppressant drugs such as cyclosporin A and FK506. Calcineurin controls the translocation of nuclear factors of activated T cells (NFAT), a family of transcriptional activators that control the expression of cytokine genes essential to immune response, from the cytosol into the nucleus of activated T cells. Calcineurin has been proposed to play an important role in mediating calcium activated cell death.

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Availability: In stock

Price: €486.71
Size: 100 ug
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