Calcineurin B antibody (10R-C107B)

Mouse monoclonal Calcineurin B antibody

Synonyms Monoclonal Calcineurin B antibody, Anti-Calcineurin B antibody
Specificity Human calcineurin B
Cross Reactivity Human, mouse, rat
Applications WB
Immunogen Calcineurin B antibody was raised in mouse using E. coli-derived recombinant human calcineurin B as the immunogen.

Specifications

Host Mouse
Clone 323417
Isotype IgG2a
Form & Buffer Lyophilized from a 0.2 u filtered solution in PBS with 5% trehalose. Reconstitute with sterile PBS.

Usage & Assay Information

Usage Recommendations WB: 0.5 ug/ml

Storage & Safety

Storage Store at -20 deg C until reconstitution. Following reconstitution product may be stored at 4 deg C in the short term. For long term storage aliquot and freeze at -20 deg C. Avoid repeated freeze/thaw cycles.

General Information

Biological Significance Calcineurin (CN) is a protein phosphatase also known as protein phosphatase 3, PPP3CA, and formerly known as protein phosphatase 2B (PP2B). It activates the T cells of the immune system and can be blocked by drugs. Calcineurin activates NFATc (Nuclear Factor of Activated T cell, cytoplasmic), a transcription factor, by dephosphorylating it. The activated NFATc is then translocated into the nucleus, where it upregulates the expression of interleukin 2 (IL-2), which, in turn, stimulates the growth and differentiation of T cell response. Calcineurin is the target of a class of drugs called calcineurin inhibitors, which includes ciclosporin, pimecrolimus and tacrolimus.

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Availability: In stock

Price: €395.16
Size: 100 ug
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