Calcitonin antibody (10-2268)
Recombinant Fab monoclonal Calcitonin antibody
Overview
Overview
| Synonyms | Monoclonal Calcitonin antibody, Anti-Calcitonin antibody, CALCA antibody, CALC1 antibody, CGRP antibody, CGRP-I antibody, CGRP1 antibody, CT antibody, KC antibody, Calcitonin 1 antibody, thyrocalcitonin antibody |
|---|---|
| Specificity | Human |
| Cross Reactivity | Detects Procalcitonin but its sandwich pair partner, 10-2269 does not. |
| Protein Type | Recombinant |
| Applications | ELISA |
| Assay Information | Calcitonin antibody pair: 10-2269 can be used as the capture antibody with 10-2268 as the detection antibody for detection of human Calcitonin in ELISA |
Specifications
| Host | Mouse |
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| Clone | M72051 |
| Isotype | IgG1 kappa - Fab fragment |
| Expression System | E.coli |
| Grade & Purity | > 95% pure |
| Method of Purification | Calcitonin antibodies screened using Phage Display system. Expressed in and purified from E. coli. |
| Tag/Conjugate | His tag |
| Form & Buffer | Supplied as liquid in 50 mM Potassium Phosphate, 10 mM Boric Acid, 150 mM NaCl, pH 7 |
| Concentration | > 1 mg/ml |
Storage & Safety
| Storage | Store at -20 deg C in small aliquots. Avoid repeated freeze thawing. |
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General Information
| Biological Significance | Calcitonin is a 32-amino acid linear polypeptide hormone that is produced in humans primarily by the parafollicular cells (also known as C-cells) of the thyroid, and in many other animals in the ultimobranchial body. It acts to reduce blood calcium (Ca2+), opposing the effects of parathyroid hormone (PTH). Calcitonin antibody was produced as a recombinant Fab monoclonal antibody in a Phage Display system. This anti-Calcitonin antibody is used for detection of human Calcitonin in ELISA. The concentration of the antibody ranges from 1 mg/ml to 25 mg/ml depending on the lot. Recombinant Fab monoclonal antibodies have a number of advantages over standard antibodies including; improved scale up for batch consistency, more efficient binding so less antibody required, more accurate binding meaning fewer conjugation issues, less non specific due to removal of the Fc region, more flexibility for purification and labeling through a C-terminal His tag. |
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