Carbonyl reductase 3 protein (His tag) (80R-1166)
Purified recombinant Human Carbonyl reductase 3 protein
|Synonyms||hCBR3 protein, NADPH-dependent carbonyl reductase protein, EC 18.104.22.168 protein, CBR3 protein, Carbonyl reductase (NADPH) 3 protein, Short chain dehydrogenase/reductase family 21C member 2., Carbonyl reductase (NADPH) 3 EC 22.214.171.124 protein, SDR21C2 protein, NADPH dependent carbonyl reductase 3 protein, Carbonyl reductase 3 protein|
Coomassie Blue stained SDS-PAGE of Carbonyl reductase 3 protein (His tag) (80R-1166)
Figure annotation denotes ug of protein loaded and % gel used.
|Residues||1-277 amino acids: MGSSHHHHHH SSGLVPRGSH MSSCSRVALV TGANRGIGLA IARELCRQFS GDVVLTARDV ARGQAAVQQL QAEGLSPRFH QLDIDDLQSI RALRDFLRKE YGGLNVLVNN AAVAFKSDDP MPFDIKAEMT LKTNFFATRN MCNELLPIMK PHGRVVNISS LQCLRAFENC SEDLQERFHS ETLTEGDLVD LMKKFVEDTK NEVHEREGWP NSPYGVSKLG VTVLSRILAR RLDEKRKADR ILVNACCPGP VKTDMDGKDS IRTVEEGAET PVYLALLPPD ATEPQGQLVH DKVVQNW|
|Grade & Purity||> 95% pure|
|Molecular Weight||33 kDa (297aa), confirmed by MALDI-TOF.|
|Form & Buffer||Supplied as a liquid in 20mM Tris-HCl buffer, pH 8.0, containing 10% glycerol.|
Storage & Safety
|Storage||Store at 4 deg C for short term storage (1/2 weeks). Aliquot and store at -20 deg C or - 70 deg C for long term storage. Avoid repeated freeze/thaw cycles.|
|Biological Significance||Carbonyl reductase 3(CBR3) is one of several monomeric NADPH-dependent oxidoreductases. This protein catalyzes the reduction of a large number of biologically and pharmacologically active carbonyl compounds to their corresponding alcohols. It also contains three exons spanning 11.2 kilobases and is closely linked to another carbonyl reductase gene – CBR1. Some studies suggest that it mediates 9-cis-retinoic acid-induced cytostatis and is a potential prognostic marker for oral malignancy. Recombinant human CBR3, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography.|
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