Cardiotrophin 1 protein (30R-AC075)

Purified recombinant Human Cardiotrophin 1 protein

Synonyms Cardiotrophin 1, CT-1 protein, Cardiotrophin-1 protein, Cardiotrophin-1 protein, Cardiotrophin-1, Cardiotrophin 1 protein, Cardiotrophin 1
Species Human
Protein Type Recombinant
Applications User optimized

Specifications

Residues Region of Cardiotrophin 1 protein corresponding to amino acids MSRREGSLED PQTDSSVSLL PHLEAKIRQT HSLAHLLTKY AEQLLQEYVQ LQGDPFGLPS FSPPRLPVAG LSAPAPSHAG LPVHERLRLD AAALAALPPL LDAVCRRQAE LNPRAPRLLR RLEDAARQAR ALGAAVEALL AALGAANRGP RAEPPAATAS AASATGVFPA KVLGLRVCGL YREWLSRTEG DLGQLLPGGS A.
Expression System E.coli
Grade & Purity > 98% pure
Molecular Weight 21.5 kDa
Form & Buffer Supplied as a lyophilized powder.

Usage & Assay Information

Bioactivity The ED50 as determined by the dose-dependent proliferation of TF-1 cells was approximately 1.0 ng/ml, corresponding to a specific activity of approximately 1 x 10^6 units/mg.

Storage & Safety

Storage Store at 4 deg C until reconstitution. Following reconstitution aliquot and freeze at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles.
Endotoxin Levels Endotoxin level is less than 0.1 ng per ug (1 EU/ug).

General Information

Biological Significance CT-1 is a member of the IL6 family of cytokines which also includes LIF, CNTF, OSM (Oncostatin M), IL11, IL6 and possibly NT-1/ BSF-3. CT-1 is a pleiotropic cytokine which is expressed in various tissues including the adult heart, skeletal muscle, ovary, colon, prostate and fetal lung and signals through the LIF receptor and the gp130 receptor subunit. CT-1 has the ability to induce cardiac myocyte hypertrophy, and enhances the survival of cardiomyocyte and different neuronal populations. Biologically active human CT-1 is synthesized as a 201 amino acid polypeptide lacking a hydrophobic N-terminal secretion signal sequence.

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Availability: In stock

Price: €211.69
Size: 10 ug
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