Caspase 1 antibody (20R-1427)

Rabbit polyclonal Caspase 1 antibody

Synonyms Polyclonal Caspase 1 antibody, Anti-Caspase 1 antibody, Caspase-1 antibody, Cysteine-Aspartic Acid Protease antibody, Caspase 1, Caspase 1,Caspase -1,Caspase 1 antibody, Caspase -1 antibody
Specificity The immunoaffinity purified antibody recognizes 45 kDa pro-Caspase-1 and the 20 kDa cleaved product.
Cross Reactivity Human, Mouse, Rat
Applications IF, IP, WB
Immunogen Caspase 1 antibody was raised in Rabbit using synthetic peptide surrounding amino acid 132 of human caspase-1 in Accession NP_150636 as the immunogen.
Assay Information Caspase 1 Blocking Peptide, catalog no. 33R-10437, is also available for use as a blocking control in assays to test for specificity of this Caspase 1 antibody

Specifications

Host Rabbit
Method of Purification Caspase 1 antibody was purified by affinity purification.
Form & Buffer Supplied in PBS buffer, pH 7.2, containing 30% glycerol, 0.5% BSA, 0.01% thimerosal.
Concentration 200 ug/ml

Usage & Assay Information

Usage Recommendations IF: 10-20 ug/ml, IP: 4-8 ug/ml, WB: 0.5-4 ug/ml

Storage & Safety

Storage Store at -20 deg C. For long-term storage, aliquot and freeze at -70 deg C. Avoid repeated freeze/thaw cycles.

General Information

Biological Significance Caspase family of cysteine proteases has been shown to play a key role in apoptosis. Caspase 1 (ICE, interleukin 1 converting enzyme) is the mammalian caspase responsible for the proteolytic conversion of the proforms of interleukin 1 and IL 18 into active cytokines. Like other caspases, Caspase 1 itself is synthesized as a pro enzyme that is cleaved during activation into a large (20 kDa) and small (10 kDa) subunits. The cellular role of Caspase 1 appears limited to cytokine activation as they do not have obvious roles in apoptosis.

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Availability: In stock

Price: €470.35
Size: 100 ug
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