Caspase 1 antibody was raised in Rabbit using a synthetic peptide corresponding to a sequence at the N-terminal of human Caspase 1(p20) as the immunogen
Optimal conditions to be determined by the end user
Storage & Safety
Storage
Store at 4 deg C for short term storage. For long term storage aliquot and store at -20 deg C, avoid repeated freeze/thaw cycles.
General Information
Biological Significance
Caspase family of cysteine proteases has been shown to play a key role in apoptosis. Caspase 1 (ICE, interleukin 1 converting enzyme) is the mammalian caspase responsible for the proteolytic conversion of the proforms of interleukin 1 and IL 18 into active cytokines. Like other caspases, Caspase 1 itself is synthesized as a pro enzyme that is cleaved during activation into a large (20 kDa) and small (10 kDa) subunits. The cellular role of Caspase 1 appears limited to cytokine activation as they do not have obvious roles in apoptosis.