Caspase 4 antibody (70R-12500)
Affinity purified Rabbit polyclonal Caspase 4 antibody
Overview
Overview
| Synonyms | Polyclonal Caspase 4 antibody, Anti-Caspase 4 antibody, Caspase -4 antibody, caspase 4 apoptosis-related cysteine peptidase antibody, protease TX antibody, Caspase 4, caspase-4 antibody, Caspase 4 antibody, ICEREL-II antibody, CASP-4 antibody, Caspase -4, ICE(rel)II antibody, TX antibody, apoptotic cysteine protease Mih1/TX antibody, ICE(rel)-II antibody, CASP4 antibody, caspase 4 apoptosis-related cysteine protease antibody, ICH-2 antibody, Caspase 4, protease ICH-2 antibody, Mih1/TX antibody |
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| Cross Reactivity | Human |
| Applications | ICC, IF, IHC-P, WB |
| Immunogen | Caspase 4 antibody was raised in rabbit using a synthetic peptide corresponding to a region within amino acids 68 and 162 of Caspase 4 |
Images
Specifications
| Host | Rabbit |
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| Isotype | IgG |
| Method of Purification | Caspase 4 antibody was purified by antigen-affinity chromatography |
| Molecular Weight | 43 kDa |
| Form & Buffer | Supplied as a concentrated soloution containing 1X PBS, 1% BSA, 20% Glycerol (pH 7.0). 0.01% Thimerosal was added as a preservative. |
| Concentration | 1 mg/ml |
Usage & Assay Information
| Usage Recommendations | IF:1:100-1:200, ICC:1:100-1:200, IHC-P: 1:100-1:500, WB: 1:500-1:3000 |
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Storage & Safety
| Storage | Store at 4 deg C for short term storage. Aliquot and store at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles. |
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General Information
| Biological Significance | This gene encodes a protein that is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain and a large and small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This caspase is able to cleave and activate its own precursor protein, as well as caspase 1 precursor. When overexpressed, this gene induces cell apoptosis. |
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