Caspase 8 antibody (70R-13850)
Affinity purified Rabbit polyclonal Caspase 8 antibody
Overview
Overview
| Synonyms | Polyclonal Caspase 8 antibody, Anti-Caspase 8 antibody, Caspase -8 antibody, Caspase-8 antibody, Cysteine-Aspartic Acid Protease 8 antibody, Caspase 8 antibody, Caspase 8, Caspase 8, Caspase -8 |
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| Applications | WB |
| Immunogen | Caspase 8 antibody was raised in Rabbit using a synthetic peptide corresponding to a sequence in the middle region of human Caspase-8(P18), different to the related Rabbit sequence by a single amino acid, as the immunogen |
Images
Western Blot analysis using Caspase 8 antibody (70R-13850)
Lane 1: Rat Thymus Tissue Lysate; Lane 2: Rat Liver Tissue Lysate; Lane 3: MCF-7 Cell Lysate; Lane 4: Hela Cell Lysate; Lane 5: SMMC Cell Lysate; Lane 6: Jurkat Cell Lysate; Lane 7: Colo320 Cell Lysate
Specifications
| Host | Rabbit |
|---|---|
| Isotype | IgG |
| Method of Purification | Caspase 8 antibody was purified by affinity chromatography |
| Form & Buffer | Supplied in lyophilized form |
Usage & Assay Information
| Usage Recommendations | Optimal conditions to be determined by the end user |
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Storage & Safety
| Storage | Store at 4 deg C for short term storage. For long term storage aliquot and store at -20 deg C, avoid repeated freeze/thaw cycles. |
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General Information
| Biological Significance | Caspase family of cysteine proteases has been shown to play a key role in apoptosis. Caspase 8 is a 55 kDa cytosolic protein that is synthesized as an inactive pro enzyme. Activation of Caspase 8 involves a two step proteolysis: the cleavage of Caspase 8 to generate a 43 and a 12 kDa fragment which is further processed to 10 kDa. The p43 is then cleaved to yield p26 and the release of the active site containing p18. |
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