CBFA2T2 antibody (70R-13232)
Affinity purified Rabbit polyclonal CBFA2T2 antibody
Overview
Overview
| Synonyms | Polyclonal CBFA2T2 antibody, Anti-CBFA2T2 antibody, MTGR1 antibody, MTG8-like protein antibody, myeloid translocation-related protein 1 antibody, EHT antibody, ETO homolog on chromosome 20 antibody, CBFAT 2, p85 antibody, CBFAT-2, DKFZp313F2116 antibody, myeloid translocation gene-related protein 1 antibody, MTG8-related protein 1 antibody, CBFA2T2, CBFAT-2 antibody, CBFAT 2 antibody, CBFA2T2 antibody, ZMYND3 antibody |
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| Cross Reactivity | Human |
| Applications | ICC, IF, WB |
Images
Specifications
| Host | Rabbit |
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| Isotype | IgG |
| Method of Purification | CBFA2T2 antibody was purified by antigen-affinity chromatography |
| Molecular Weight | 67 kDa |
| Form & Buffer | Supplied as a concentrated soloution containing 0.1M Tris, 0.1M Glycine, 10% Glycerol (pH 7.0). 0.01% Thimerosal was added as a preservative. |
| Concentration | 1 mg/ml |
Usage & Assay Information
| Usage Recommendations | IF:1:100-1:200, WB: 1:500-1:3000 |
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Storage & Safety
| Storage | Store at 4 deg C for short term storage. Aliquot and store at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles. |
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General Information
| Biological Significance | In acute myeloid leukemia, especially in the M2 subtype, the t translocation is one of the most frequent karyotypic abnormalities. The translocation produces a chimeric gene made up of the 5'-region of the RUNX1 gene fused to the 3'-region of the CBFA2T1 gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. The protein encoded by this gene binds to the AML1-MTG8 complex and may be important in promoting leukemogenesis. |
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