CBFA2T2 antibody (70R-13232)

Affinity purified Rabbit polyclonal CBFA2T2 antibody

Synonyms Polyclonal CBFA2T2 antibody, Anti-CBFA2T2 antibody, MTGR1 antibody, MTG8-like protein antibody, myeloid translocation-related protein 1 antibody, EHT antibody, ETO homolog on chromosome 20 antibody, CBFAT 2, p85 antibody, CBFAT-2, DKFZp313F2116 antibody, myeloid translocation gene-related protein 1 antibody, MTG8-related protein 1 antibody, CBFA2T2, CBFAT-2 antibody, CBFAT 2 antibody, CBFA2T2 antibody, ZMYND3 antibody
Cross Reactivity Human
Applications ICC, IF, WB

Images

Immunofluorescent staining using CBFA2T2 antibody (70R-13232)

Immunofluorescence analysis of paraformaldehyde-fixed HeLa, using CBFA2T2 antibody at 1:200 dilution.

Specifications

Host Rabbit
Isotype IgG
Method of Purification CBFA2T2 antibody was purified by antigen-affinity chromatography
Molecular Weight 67 kDa
Form & Buffer Supplied as a concentrated soloution containing 0.1M Tris, 0.1M Glycine, 10% Glycerol (pH 7.0). 0.01% Thimerosal was added as a preservative.
Concentration 1 mg/ml

Usage & Assay Information

Usage Recommendations IF:1:100-1:200, WB: 1:500-1:3000

Storage & Safety

Storage Store at 4 deg C for short term storage. Aliquot and store at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles.

General Information

Biological Significance In acute myeloid leukemia, especially in the M2 subtype, the t translocation is one of the most frequent karyotypic abnormalities. The translocation produces a chimeric gene made up of the 5'-region of the RUNX1 gene fused to the 3'-region of the CBFA2T1 gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. The protein encoded by this gene binds to the AML1-MTG8 complex and may be important in promoting leukemogenesis.

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Images

  • <div><font face=Calibri size=2>Immunofluorescent staining using CBFA2T2 antibody (70R-13232)</font></div>     | Immunofluorescence analysis of paraformaldehyde-fixed HeLa, using CBFA2T2 antibody at 1:200 dilution.
  • <div><font face=Calibri size=2>Western blot analysis using CBFA2T2 antibody (70R-13232)</font></div>     | Western blot analysis of 30 ug of whole cell lysate (A: Hep G2) using a 7.5 % SDS PAGE gel and CBFA2T2 antibody at a dilution of 1:1000

Availability: In stock

Price: €323.11
Size: 100 ul
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