CCL2/MCP1 protein (His tag) (80R-1110)
Purified recombinant Human CCL2/MCP1 protein
|Synonyms||, SCYA2 protein, CCL2/MCP1, GDCF-2 protein, HC11 protein, CCL/MCP1-2, MCP-1 protein, CCL2 protein, small inducible cytokine A2 (monocyte chemotactic protein 1 homologous to mouse Sig-je) protein, CCL/MCP1 2, Chemokine (C-C motif) ligand 2 protein, MGC9434 protein, MCAF protein, CCL/MCP1-2 protein, MCP1 protein, SMC-CF protein, CCL/MCP1 2 protein|
Coomassie Blue stained SDS-PAGE of CCL2/MCP1 protein (His tag) (80R-1110)
Figure annotation denotes ug of protein loaded and % gel used.
|Residues||24-99 amino acids: MGSSHHHHHH SSGLVPRGSH MQPDAINAPV TCCYNFTNRK ISVQRLASYR RITSSKCPKE AVIFKTIVAK EICADPKQKW VQDSMDHLDK QTQTPKT|
|Grade & Purity||> 95% pure|
|Molecular Weight||10.9 kDa (97 aa), confirmed by MALDI-TOF.|
|Form & Buffer||Supplied as a liquid in 20mM Tris-HCl buffer, pH 8.0, containing 1mM DTT, and 20% glycerol.|
Storage & Safety
|Storage||Store at 4 deg C for short term storage (1/2 weeks). Aliquot and store at -20 deg C or - 70 deg C for long term storage. Avoid repeated freeze/thaw cycles.|
|Endotoxin Levels||< 1.0 EU per ug of protein (determined by LAL method)|
|Biological Significance||Chemokine (C-C motif) ligand 2 (CCL2) is a small cytokine belonging to the CC chemokine family that is also known as monocyte chemotactic protein-1 (MCP-1). CCL2 recruits monocytes, memory T cells, and dendritic cells to sites of tissue injury and infection. It has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis and atherosclerosis. It binds to chemokine receptors CCR2 and CCR4. Recombinant human CCL2 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.|
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