CCL5 protein (Mouse) (30R-2225)

Purified recombinant Mouse CCL5 protein

Synonyms CCL 5, CCL-5 protein, CCL5, CCL-5 protein, CCL-5, CCL 5 protein
Specificity Human
Species Mouse
Protein Type Recombinant
Applications Functional Assay
Assay Information This recombinant mouse IL-16 has been tested in bioassays for chemoattractant activity with maximal activity observed between 10-100 ng/ml.

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Functional Assay using CCL5 protein (Mouse) (30R-2225)

Chemotaxis of mCCR5-transfected CHO cells in response to Mouse CCL5 protein.

Specifications

Expression System E.coli
Grade & Purity > 98% pure
Method of Purification CCL5 protein was purified by affinity chromatography.
Molecular Weight 8 kDa
Form & Buffer Supplied as a sterile liquid with 0.1 M glycine with 1% BSA, pH3.0, 0.22 um filtered.

Usage & Assay Information

Bioactivity The bioactivity of this protein was determined by transmigration assay of human monocytes. Maximum chemotaxis is observed at less than or equal to 100 ng/ml.

Storage & Safety

Storage Store at -70 deg C or less.
Endotoxin Levels Less than 0.01 ng/ug cytokine as determined by the LAL assay.

General Information

Biological Significance Mouse CCL-5, or RANTES, is an 8 kDa monomeric protein that belongs to the CC- family of chemokines. The chemokines in this family share a common g-protein coupled receptor, CCR5, which they bind to through a conserved core region. In humans, CCR5 is also known to be the co-receptor through which the HIV virus enters the cell. This effect is blocked by the binding of RANTES to CCR5, making these proteins potential targets for HIV therapy. RANTES plays an important role in the immune response by initiating the recruitment of leukocytes to the site of inflammation. It is a chemoattractant for T cells, monocytes, and dendritic cells, and may increase the cytotoxicity and promote proliferation of NK cells. It is reported to be produced by fibroblasts, platelets, and T cells. RANTES is also involved in the progression and metastasis of some forms of cancer, and constitutive expression has been demonstrated in some malignant tumors. Human and mouse RANTES share 85% sequence homology and demonstrate cross-species activity.

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  • Functional Assay using CCL5 protein (Mouse) (30R-2225) | Chemotaxis of mCCR5-transfected CHO cells in response to Mouse CCL5 protein.

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Price: €292.02
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