CD11b antibody (10R-6348)

Rat monoclonal CD11b antibody

Synonyms Monoclonal CD11b antibody, Anti-CD11b antibody, CR3 antibody, CD-11b antibody, CD-11b, Ma-1c antibody, CD 11b, ITGAM antibody, CD11b, integrin alpha M antibody, CD 11b antibody, Integrin alpha M antibody
Specificity Mouse
Applications FC
Assay Information A test is defined as the amount (ug) of antibody that will stain a cell sample in a final volume of 100 ul. Cell number should be determined empirically but can range from 105 to 108 cells/test. It is recommended that the antibody be carefully titrated for optimal /formance in the assay of interest.

Images

Flow Cytometric analysis using CD11b antibody (10R-6348)

Staining of mouse bone marrow with CD11b antibody (FITC) (left) (PE) (right). Appropriate Isotype Controls were used (open histogram). Cells in the myeloid population were used for anaysis.

Specifications

Host Rat
Clone M1/70
Isotype IgG2b kappa
Method of Purification CD11b antibody was purified by affinity chromatography.
Form & Buffer Supplied in aqueous buffer with 0.09% sodium azide, may contain carrier protein/stabilizer.
Concentration 500 ug/ml

Usage & Assay Information

Usage Recommendations FC: = 0.25 ug/test

Storage & Safety

Storage Store at 2-8 deg C. Do not freeze. Protect from light.

General Information

Biological Significance The M1/70 monoclonal antibody reacts with mouse CD11b, the 165-170 kDa integrin alphaM. CD11b non-covalently associates with CD18 to form alphaMbeta2 integrin and binds to CD54, C3bi, and fibrinogen. Mac-1 is expressed by macrophages, NK cells, granulocytes, activated lymphocytes and mouse B-1 cells in the peritoneal cavity. M1/70 is also cross-reactive to human CD11b, and can be used for the detection of this antigen on human peripheral blood monocytes, granulocytes, and a subset of NK cells. Through interactions with its ligands, CD11b participates in adhesive cell interactions.

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Images

  • Flow Cytometric analysis using CD11b antibody (10R-6348) | Staining of mouse bone marrow with CD11b antibody (FITC) (left) (PE) (right). Appropriate Isotype Controls were used (open histogram). Cells in the myeloid population were used for anaysis.

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Price From: Price: €95.71
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